Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01998204

Enrollment

Registered

2013-11-28

Start date

2012-01-31

Completion date

2013-06-30

Last updated

2013-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Keywords

Parkinson's disease, propofol, deep brain stimulator

Brief summary

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia * non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia

Exclusion criteria

* ASA score higher than Class III * predicted difficult airway * hearing impairment * inability to corporate with instruction * alcohol or drug abuser * patients refusing to provide informed consent

Design outcomes

Primary

Measure	Time frame	Description
Consciousness status	Participants will be monitored during the period of propofol infusion, an expected average of less than 10 min	Consciousness status is evaluated by the observer's assessment of alertness and sedation score (OAA/S).

Countries

China

Outcome results