Acute Coronary Syndromes, Menopause
Conditions
Keywords
acute coronary syndrome, coronary arteriography, menopause
Brief summary
The Ladies ACS study will investigate the relation between age at menopause and severity of coronary artery disease in menopausal women with acute coronary syndromes and clinical indication to coronary angiography.
Detailed description
Multicenter prospective study in consecutive patients hospitalized with a wide spectrum of ACS and clinical indication to coronary angiography. Consecutive patients older than 55 years with an ACS undergoing coronary angiography are eligible for the study, irrespective of subsequent revascularization. Eligible are women and men with a 2:1 enrolment ratio. Patients will be stratified according to gender and age, including four age categories: 55-64, 65-74, 75-85 and \>85 years. Each age category will include 200 patients, and enrolment in each category will be stopped once this number has been reached. A specific electronic web-based CRF will collect clinical and procedural data. Clinical data input will take place at the participating Centers. Angiographic data input will be performed at rthe angiographic corelab, blinded of clinical data. The e-CRF will collect data on * the characteristics of the ACS * the relevant risk factors for CAD and known prognostically relevant variables * prior clinical history (prior MI, PCI, CABG, heart failure, stroke) * in women fertility history will be captured by specific items, including age at first and last menstrual period, past use of oral contraceptives, ongoing and past hormone replacement therapy (HRT) and whether they had undergone a hysterectomy and/or oophorectomy, as well as information on the number of full-term pregnancies (the sum of live births and stillbirths). Age at menarche is defined as the age at the first menstrual period. Reproductive life span is automatically calculated calculated by subtracting the age at menarche from the age at menopause. The presence of hot flushes, their severity and duration in years will be also captured. The extent of coronary artery disease will be evaluated at a central corelab using the Gensini score and the SYNTAX score
Interventions
None listed
Sponsors
Azienda USL Reggio Emilia - IRCCS
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients \>55 years of age with all of the following characteristics: * symptoms suggestive of acute myocardial ischemia within the previous 48 hours. * The diagnosis of an ACS must be confirmed by a typical rise and fall in serum troponin levels as defined by the Third Universal Definition of Myocardial Infarction. * ECG signs of myocardial ischemia defined as either transient or persistent ST segment elevation or depression \>0.5 mm (but \>1 mm in the case of ST-segment elevation), or persistent and definite T-wave inversion \>1 mm, including the pseudonormalization of a previously negative T-wave, in ≥2 contiguous leads.
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extent of coronary artery disease at angio corelab (Gensini and SYNTAX score) | 1 day | The primary study end-point will be the severity of coronary artery disease, as appraised by the Gensini score |
Countries
Italy
Outcome results
None listed