Intubating Conditions, Patient Satisfaction, Postoperative Myalgia
Conditions
Keywords
Succinylcholine, Rocuronium, Rigid Bronchoscopy
Brief summary
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM) as well as patient satisfaction for these two muscle relaxants.
Interventions
DRUGSuccinylcholine
Anaesthesia is induced and maintained with propofol (1-2 mg/kg) and remifentanil (0,5 µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. After induction of anaesthesia the patient receives muscle relaxant according to the study group.
DRUGRocuronium 0,3
General anaesthesia is induced and maintained with propofol (1-2mg/kg) and remifentanil (0,5µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. The Patient receives the muscle relaxant according to the study group.
DRUGRocuronium 0,6
General anaesthesia is induced and maintained with propofol (1-2mg/kg) and remifentanil (0,5µg/kg). The study arm is immobilized and after cleaning the skin a dual electrode for peripheral nerve stimulation is placed over the ulnar nerve near the wrist. Neuromuscular monitoring is performed with accelerometry. The Patient receives the muscle relaxant according to the study group.
Sponsors
Dr. Horst Schmidt Klinik GmbH
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* age \> 18 yr * scheduled for elective rigid bronchoscopy
Exclusion criteria
* known neuromuscular disease * significant hepatic or renal dysfunction * family history of malignant hyperthermia * known allergy to one of the drugs used in this protocol * pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intubating Condition | after induction of general anaesthesia (after 3-5 minutes) | The intubating conditions will be measured using the scoring system proposed for Good Clinical Research Practice using the following variables: conditions of inserting the rigid bronchoscope, vocal cord position and coughing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Myalgia | 72 hours after intervention | The severity of POM is measured by using a four-point-scale: 0\. no myalgia 1. minor pain limited to one area of the body 2. muscle pain or stiffness noticed spontaneously by the patient, which may have required analgesic therapy 3. generalized, severe or incapacitating discomfort |
Other
| Measure | Time frame | Description |
|---|---|---|
| Patient satisfaction | 72 hours after intervention | measurement on a numeric ten point scale |
Countries
Germany
Outcome results
None listed