Postprandial Blood Cell Transcriptome of Normal Weight and Obese Subjects to 3 Caloric Doses of a High-fat Meal

Identification of Nutritional Health Biomarkers for Metabolic Flexibility in Blood - a Randomized, Postprandial, Caloric Dose-response Strategy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01995110

Enrollment

Registered

2013-11-26

Start date

2011-03-31

Completion date

2013-11-30

Last updated

2014-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional Intervention, Obesity

Brief summary

The study will quantitatively evaluate the metabolic response of normal weight and obese subjects to three high-fat meals differing in caloric dose by analysing the postprandial blood transcriptome.

Interventions

OTHERhigh-fat meal A

OTHERhigh-fat meal B

OTHERhigh-fat meal C

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

25 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

for normal weight subjects: * age 25-50 * 20\<BMI\>25 * waist circumference \<94cm Inclusion Criteria for obese subjects: * age 25-50 * 30\<BMI\>40 * waist circumference \>102cm

Exclusion criteria

for both groups: * physiological or psychological diseases * allergies to food or intolerance to high-fat meal * vegetarians, vegans * chronic intake of drugs * smokers * diabetes mellitus type I and II * debiliating kidney disease * debiliating liver disease * clinically established coronary heart diseases * ingestion of vitamins or dietary supplements during the course of the study

Design outcomes

Primary

Measure	Time frame	Description
blood cell transkriptome/ gene-expression	0h, 2h, 4h, 6h	* differently expressed genes between normal weight and obese subjects at baseline * changes in gene-expression 2, 4 and 6h after consumption

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026