Prevalence of MTHFR Polymorphisms in Venous Disease

Prevalence of MTHFR Polymorphisms in Venous Disease With or Without Concomitant Thrombosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01993914

Acronym

MTHFR

Enrollment

Registered

2013-11-25

Start date

2011-02-28

Completion date

2014-11-30

Last updated

2014-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MTHFR, Thrombosis, Varicose Veins, Venous Disease

Brief summary

The etiologies of varicose veins and the progression to more serious forms of chronic venous disease and identification of appropriate diagnostic tests to better aid patient management by identifying individuals who may benefit from more aggressive treatment and/ or prophylactic measures.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age 18 or over * No venous disease (N=30); or C2-C3 venous disease (N=30); or C4-C6 venous disease (N=30)

Exclusion criteria

* Pregnancy * Cancer * Chronic obstructive pulmonary disease (COPD) * Any systemic inflammatory disease * Any of the following within the previous 30 days: * Trauma * Any surgery * Periods of prolonged inactivity

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of MTHFR mutation between patients	Baseline	Determine whether the prevalence of the MTHFR mutation differs between patient with varicose veins compared to controls and with or without superficial vein thrombosis.

Countries

United States

Outcome results