Osteoarthritis
Conditions
Keywords
adipocytokines, osteoarthritis, inflammation, ultrasonography
Brief summary
The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa, interleukine 6 and high sensibility reactive c protein in the synovial fluid of knee osteoarthritis patients, and compare with the inflammation detected with ultrasonography evaluation of the joint. In last years, some studies appeared focusing on the role of adipocytokines in osteoarthritis and they correlated adipocytokines with cartilage degradation and x-ray degree; in our study we will focused in the importance of adipocytokines in the inflammatory changes more than in joint destruction.
Interventions
OTHERarthrocentesis
The made a diagnostic arthrocentesis to all patient we included
OTHERultrasonography of the knee
We explored the affected knee with an ultrasound explanation in order to describe inflammatory changes based on standard examination.
Sponsors
Parc Taulí Hospital Universitari
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 81 Years
Healthy volunteers
No
Inclusion criteria
* aged 50 to 81 * primary osteoarthritis of the knee * synovial effusion in examination * patient who have the results in our database
Exclusion criteria
* any other rheumatic conditions as rheumatoid arthritis or another inflammatory disease * secondary knee osteoarthritis * history of knee surgery * any conditions that at investigator criteria exclude the patient from study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid | We determine adipocytoquines in one month, all patients in the same determination kit | We have all the synovial fluid freeze, so now we have to determine the levels of everyone. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Knee inflammation parameters detected by ultrasonography | three months | We performed the ultrasonography evaluation at the same time than the visit were realized, and we have the results in a data base, so we will wait for the adipocytokine results and we will compare with ultrasound evaluation |
| To determine additional classic parameters of inflammation in synovial fluid as Interleukine 1 beta, Interleukine 6 and tumor necrosis factor alfa | We determine this inflammatory parameters in one month in all patient at the same time | We will use classic inflammation parameters to compare with adipocytokine levels |
Countries
Spain
Contacts
Primary ContactJoan Calvet, Dr
Backup ContactCristobal Orellana, Dr
Outcome results
None listed