Obesity, Overweight
Conditions
Keywords
Resistant Starch, Antioxidant Status, Insulin Resistance, Overweight, Obesity
Brief summary
The aim of this study is to evaluate whether supplementation with resistant starch improves biomarkers associated with antioxidant status and insulin resistance in subjects with overweight and obesity.
Interventions
DIETARY_SUPPLEMENTHi-maize resistant starch
13.5 g/day
DIETARY_SUPPLEMENTMaltodextrin
13.5 g/day
Sponsors
Urmia University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Overweight and obese adults * Age: 20-50 years
Exclusion criteria
* weight loss or gain (more than10%) over the past 6 months, or weight loss (more than 5%) over the past 1 month * pregnancy, lactation or menopause * History of acute disease or clinical evidence of cancer, acute or chronic inflammatory diseases, cardiovascular disease, renal disease, liver disease, thyroid or endocrine disease * Gastrointestinal disease of which ingredients found in the study products have adverse effects on that * Use of antihypertensive, lipid lowering or glucose lowering medications * Taking antioxidant, vitamin, and/or mineral supplements * smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antioxidant status | 4 weeks | Superoxide dismutase (SOD), Plasma malondialdehyde (MDA), Total antioxidant capacity (TAC) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin resistance | 4 weeks | Fasting glucose, Fasting insulin, Insulin resistant (HOMA-IR) |
| Lipid profile | 4 weeks | Triglyceride, Total cholesterol, HDL-cholesterol, LDL-cholesterol, Total cholesterol/HDL-cholesterol |
| Blood pressure | 4 weeks | — |
| Anthropometric parameters | 4 weeks | Height, Weight, Body Mass Index (BMI), Waist circumference |
Countries
Iran
Outcome results
None listed