Negative Postprandial Effect on Endothelium After a Not-healthy Meal in Type 2 Diabetes as Affected by Training

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01991769

Enrollment

Registered

2013-11-25

Start date

2012-02-29

Completion date

2013-11-30

Last updated

2016-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Type 2

Keywords

exercise, endothelium, postprandial period

Brief summary

The purpose of this study is to examine whether exercise reduces the postprandial effects of an unhealthy meal on heart function and endothelial function. Both healthy people and type 2 diabetes subjects will during three days either carry out two different sessions of exercise training or not before ingesting an unhealthy meal high in saturated fat and fast carbohydrates. The two different exercise training modes used are high intensity interval training (HIIT) and moderate intensity training (MIT) Hypothesis: Exercise training in advance of an unhealthy meal will improve endothelial- and cardiac function in healthy and type 2 diabetes individuals. HIIT will reduce the negative postprandial effects on the endothelium more than MIT.

Interventions

BEHAVIORAL47 min moderate intensity training

BEHAVIORALexercise healthy volunteers

BEHAVIORALcontrol; no exercise training

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

40 Years to 65 Years

Healthy volunteers

Inclusion criteria

* healthy or type 2 diabetes

Exclusion criteria

* type 2 diabetes more than 10 years * unstable angina * myocardial infarction * overt cardiovascular disease. * severe valvular disease. * overt lung disease. * orthopedical- /neurological restrictions * severe disease related to diabetes type 2 (neuropathy, micro-or macroalbuminuria, retinopathy) * body mass index \>35 * severe eating disorders. * personality disturbances. * planned surgery during the project period. * patients who achieve greater than the current exercise guidelines for type 2 diabetes (210 min/week) before the start of the study. * uncontrolled hypertension * kidney failure * cardiomyopathy * smoking * patients who probably not will be able to complete the study * alcohol or drug abuse

Design outcomes

Primary

Measure	Time frame	Description
endothelial function	24 hours	measured as flow mediated dilatation (FMD) of the brachial artery using high resolution vascular ultrasound according to current guidelines

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026