Incubation of Alcohol Craving During Abstinence

The Neural Mechanisms of the Incubation of Cue-induced Craving in Alcohol Dependence

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01991704

Enrollment

Registered

2013-11-25

Start date

2011-10-31

Completion date

2013-10-31

Last updated

2013-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol Dependence

Keywords

incubation, Craving, alcohol dependence

Brief summary

In order to determine whether the 'incubation of craving' phenomenon also occurred in alcoholics, investigators employed an experimental approach to investigate the time course of cue-induced craving in alcoholism. Eighty male participants were randomly divided into Four groups, and they were assessed at 7, 14, 30, and 60 days of abstinence for cue-induced alcohol craving . Another group including 19 patients was repeatedly tested for the cue-induced alcohol craving at the above abstinence days. Other psychological and physiological measures were administered at the four abstinence time points.

Detailed description

All subjects provided written informed consent after a full explanation of the protocol design.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* met the criteria of DSM-IV for alcohol dependence * aged 18-60 years,male

Exclusion criteria

* current or past history of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) axis I disorders * with other serious physical diseases (respiratory disorders, cardiovascular disease and so on) * other drug abuse except for nicotine

Design outcomes

Primary

Measure	Time frame
changes of alcohol craving measured with visual analogue scales	abstained from alcohol for 7 days, 14 days, 30 days and 60 days

Secondary

Measure	Time frame
heart rate changes	7, 14, 30 and 60 days after abstained
blood pressure changes in different abstinence days	7, 14, 30 and 60 days after abstained
skin conductance changes in different abstinence days	7, 14, 30 and 60 days after abstained
changes of Alcohol Urge Questionnaire	7, 14, 30 and 60 days after abstained

Outcome results