Pain, Blood Pressure, Nausea, Vomiting, Arrhythmia
Conditions
Brief summary
To evaluate the efficacy of dexmedetomidine for the prevention of catheter-related bladder discomfort
Detailed description
After transurethral bladder resection, large-sized foley catheter have been used for drainage of urine and residual blood. Because of urinary catheterization, patients usually experiences catheter-related bladder discomfort defined as a burning sensation with an urge to void or discomfort in the supra-pubic region caused by catheter- related bladder irritation. Dexmedetomidine is an alpha-2 antagonist and used as an analgesic agent. The investigators try to evaluate The efficacy of dexmedetomidine for the treatment of catheter-related bladder discomfort
Interventions
DRUGDex infusion
Dexmedetomidine will be injected (1 mcg/kg for 10 minutes and afterward 0.3 mcg/kg/hr)
DRUGNS infusion
Normal saline will be infused during surgery
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for transurethral bladder resection * ASA I-III
Exclusion criteria
* Patient who disagrees to participate this investigation * Patient with severe cardiovascular disease * Patient with small-sized foley catheter (less than 18 Fr.) * Patinets with any urinary tract obstructions * Patient with hyperactive or neurogenic bladder * Patients with chronic renal failure * Patient with morbidly obese * Patients with neurogenic disorder * Patient with medications for chronic pain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The number of patients with catheter-related bladder discomfort | at postoperative 1 hour | catheter-related bladder discomfort at postoperative 1 hour was evaluated as none, mild, moderate, severe. The number of patients with mild, moderate, severe discomfort will be calculated and compared between groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Catheter-related bladder discomfort | at postoperative 0, 1, 6, 24 hours | Catheter-related bladder discomfort will be evaluated as none, mild, moderate, severe at postoperative 0, 1, 6, 24 hours. |
| Pain at suprapubic area | at postoperative 0, 1, 6, 24 hours | Pain at suprapubic area will be evaluated using NRS (0:none, 100:worst imaginable) at postoperative 0, 1, 6, 24 hours |
Countries
South Korea
Contacts
Primary ContactHyun-Chang Kim, MD
Backup ContactHee-Pyong Park, Ph.D
Outcome results
None listed