Brazil Nut Consumption in Microvascular Endothelial Function, Oxidative Stress and Metabolic Abnormalities

Effect of Brazil Nut Consumption in the Microvascular Endothelial Function, Oxidative Stress and Metabolic Abnormalities in Hypertensive and Dyslipidemic Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01990391

Enrollment

125

Registered

2013-11-21

Start date

2011-09-30

Completion date

2013-04-30

Last updated

2013-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyslipidemia, Oxidative Stress

Brief summary

The purpose this research is to check the effect of Brazil Nuts consumption in oxidative stress, metabolic abnormalities and microvascular endothelial function dyslipidemic and hypertensive patients.

Interventions

DIETARY_SUPPLEMENTBrazil nut flour

The Brazil nut group received 13g/day of Brazil nut flour during three months.

DIETARY_SUPPLEMENTPlacebo (cassava flavored flour)

The group placebo (cassava flour flavored)received 9g/day of cassava flour flavored during three months

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* adults \> 20 years old * Dyslipidemic * Hypertensive

Exclusion criteria

* Allergy to nuts * Consumption of nuts or vitamins/minerals supplement * Loss weight before the research * pregnancy * Kidney chronic disease

Design outcomes

Primary

Measure	Time frame	Description
Antioxidant biomarker	Change from Baseline at 12 weeks.	Change from Baseline plasma Gluthathione Peroxidase activity (nmol/min/ml) at 12 weeks, samples were stocked at -80 degrees.

Secondary

Measure	Time frame	Description
Oxidative stress biomarker	Change from Baseline at 12 weeks.	The change from baseline plasma 8-isoprostane (pg/ml) at 12 weeks, samples were stocked at -80 degrees.
microvascular endothelial function	Change from baseline at 12 weeks	Microvascular reactivity was evaluated using an Laser Speckle Contrast Imaging system with a laser wavelength of 785 nm in combination with the iontophoresis (increasing anodal currents of 30, 60, 90, 120, 150 and 180μA for 10 second intervals spaced 1 minute apart) of acetylcholine (2% v/v) for the noninvasive and continuous measurement of cutaneous microvascular perfusion changes measured in arbitrary perfusion units.

Other

Measure	Time frame	Description
Anthropometric measures	Change from baseline at 12 weeks	body weight (kg), body mass index (kg/m2) and waist circumference (cm).
Blood lipids	Change from baseline at 12 weeks	total Cholesterol (mg/dl), LDL-cholesterol (mg/dl), HDL-cholesterol (mg/dl) and triglycerides (mg/dl).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026