Sleep Deprivation
Conditions
Keywords
sleep restriction, decision making, wakefullness
Brief summary
* hypothesis: sleep restriction in healthy subject trigger alteration of decision making associated with immuno-inflammatory changes * inclusion criterias: healthy subjects, men, under 35 years, BMI\<26, no sleep troubles, intermediate chronotype * design: 12 subjects, longitudinal study 2 days of baseline, 7 night of sleep restriction (4h sleep/night), recovery (1, 2, 3 and 9 normal sleep nights). * parameters: decision making tests, reaction time, wakefulness test, biological parameters (cathecholamines, pro-inflammatory cytokines...), heart rate, blood pressure * control of sleep restriction: continuous polysomnographic survey
Interventions
OTHERSleep restriction
4 hours sleep by night during one week
Sponsors
Institut de Recherche Biomedicale des Armees
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy men, \< 35 yr old, BMI\<26, intermediate chronotype
Exclusion criteria
* sleep trouble, acute or chronique disease (cardiological, neurological...), women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| London tower test score (décision making) | up to 3 days | % of good score and mean response time resulting from London Tower test, assessed during baseline, sleep restriction (day 1 to day 5) and recovery (day 1 to day 3) at 10 AM |
Secondary
| Measure | Time frame |
|---|---|
| wakefulness | maintenance of wakefulness test (MWT) score observed every day during baselline, sleep restriction and recovery at 09 AM, 12 AM, 4 PM and 7 PM |
| cognitive function | up to 3 days |
| Inflammation | biological marker of inflammation levels assessed every day during baseline, sleep restriction and recovery at 08 AM |
Countries
France
Outcome results
None listed