Effect of a Probiotic-based Product on Blood Pressure

The Effect of a Probiotic-based Product on Blood Pressure and Other Known Risk Factors Linked to Cardiovascular Diseases.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01989702

Enrollment

142

Registered

2013-11-21

Start date

2010-10-31

Completion date

2011-06-30

Last updated

2013-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Pressure

Brief summary

The aim of the present study was to examine the efficacy of a probiotic-based product on either reducing hypertension or preventing a high normal blood pressure from reaching hypertensive levels.

Interventions

OTHERFermented blueberry drink

OTHERPlacebo drink

OTHERSachets with probiotic bacterial powder

OTHERSachets with placebo powder

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy individuals at the age of 40-75 years. * Blood-pressure \>140/90 mmHg that has been confirmed at 2-3 separate occasions or represents the mean value of a 24-hour measurement. * Triglycerides \>1,7 mmol/L and/or HDL \<1 mmol/L (men)/1,29 mmol/L (women). * Fasting plasma glucose levels \>5,6 mmol/L and/or waist circumference \>102 cm (men)/88 cm (women). * BMI \<40.

Exclusion criteria

* Medically treated allergy or allergy to any of the ingredients of the study product. * Medication for high levels of blood lipids. * Metabolic disease, such as type one diabetes. * Confirmed diseases of the heart, liver of kidneys. * Chronic inflammatory disease requiring medication. * Pregnant or nursing. * Regular intake of other probiotic products (5-7 days per week during the last three months before inclusion into the study).

Design outcomes

Primary

Measure	Time frame
Changes from baseline in systolic and diastolic blood pressure after 3 months of probiotic intervention	Baseline, 3 months

Secondary

Measure	Time frame
Changes from baseline of blood parameters, such as inflammatory markers and blood lipids, linked to increased risk for cardiovascular diseases	Baseline, 3 months

Other

Measure	Time frame
Effect of study product on intestinal microbiota as analysed in fecal samples	Baseline, 3 months

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026