Predisposition to Persistent Pain After Orthopaedic Surgery: Genetic Aspects

LA PREDISPOSIZIONE AL DOLORE PERSISTENTE POST OPERATORIO IN AMBITO ORTOPEDICO: ASPETTI GENETICI

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01989351

Enrollment

130

Registered

2013-11-21

Start date

2013-03-31

Completion date

2017-02-06

Last updated

2017-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Pain

Brief summary

The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS\>4 patients and to compare it to those with VAS\<4.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age \> 18 * ASA I to III

Exclusion criteria

* Contraindications to regional anesthesia procedures * Not stabilized neurological diseases * Diabetes

Design outcomes

Primary

Measure	Time frame
Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.	4 months after surgery

Secondary

Measure	Time frame
Expression frequency of OPRM1, COMT, IL1Ra	6, 12, 24, 48 hours
Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system	6, 12, 24 and 48 hours postoperatively

Countries

Italy

Outcome results