Healthy Individuals
Conditions
Brief summary
This study is intended to collect blood from healthy individuals to investigate whether variations in immune-related (inflammasome) genes affect how the immune cells found in the blood can help fight infections and prevent diseases.
Interventions
OTHERBlood Draw
Sponsors
Ohio State University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Healthy with no chronic or acute illnesses, or taking medication which in the opinion of the PI would impact the analyses being conducted. 2. At least 18 years or older. 3. Are capable of reading, understanding and providing written informed consent.
Exclusion criteria
1. Non-English speaking. 2. Individuals under 18 years old. 3. Woman who believe they are or may be pregnant. (Based on self reporting. Pregnancy testing will not be conducted for the purposes of this study) 4. Individuals experiencing acute or chronic illnesses which in the opinion of the PI would impact the analyses being conducted. 5. Currently taking prescription or over the counter medication which in the opinion of the PI would impact the analyses being conducted. 6. Individual has donated blood more than twice in the last week or the amount to be drawn will exceed the maximum allowance in the last 8 weeks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials | one visit | Our intent is to collect these cells, divide them into subtypes such as monocytes, lymphocytes and neutrophils and then to analyze their ability to respond to exogenous challenges by changing the production of proteins, the expression of genes and their ability to migrate and ingest materials. We additionally will be interested in examining the cell components that may be released from these cells during various in vitro challenges. |
Countries
United States
Outcome results
None listed