Markers of Oxidative Stress in a Early Week Miscarriage: Ischemia of Modified Albumin

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01988740

Acronym

IMA

Enrollment

180

Registered

2013-11-20

Start date

2013-11-30

Completion date

2014-04-30

Last updated

2013-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Absence of Fetal Pole on Ultrasonographic Examination., Fetal Heart Activity Absent, First Trimester Pregnancy

Keywords

Ischemia-modified albumin, Recurrent pregnancy loss, Abnormal placenta

Brief summary

The finding that ischemia-modified albumin (IMA) is increased in pre-eclamptic pregnancy suggests a role for IMA as a potential biomarker for abnormal placental development related to miscarriage.This study was undertaken to evaluate IMA levels in women with recurrent pregnancy loss (RPL).

Detailed description

Ischemia-modified albumin (IMA) measured by the albumin cobalt binding test is a relatively new biomarker in the identification of myocardial ischemia. Experimental studies have shown that pregnancies normally develop in a relatively hypoxic intrauterine environment, and the subsequent reperfusion and oxidative stress is important for physiological trophoblast development. The finding that maternal serum IMA levels are raised so early in pregnancy provides further support for IMA as a potential marker for abnormal placental development that may be related to early pregnancy loss. In this study, we aimed to evaluate maternal circulating IMA levels in women with RPL by comparing them with healthy controls.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* first trimester pregnancy * absence of fetal cardiac activity * absence of fetal pole * history of two or more unexplained first trimester miscarriages * no live births * apparently healthy women attending for antenatal care in the first trimester with at least one previous uneventful natural pregnancy

Exclusion criteria

* pre-existing diabetes or vascular disease were excluded * diagnosis of chromosomal, anatomic, endocrinologic and autoimmunologic etiology of recurrent pregnancy loss * Women with multiple pregnancy * any major or minor fetal anomaly * current smokers

Design outcomes

Primary

Measure	Time frame	Description
first trimester pregnant women	under 14 w gestation	first trimester pregnancy with absence of fetal cardiac activity or absence of fetal pole on ultrasonographic examination Patients with a history of two or more unexplained first trimester miscarriages and no live births were included in the study.

Countries

Turkey (Türkiye)

Contacts

Primary Contacthediye dağdeviren, md

hediyedagdeviren@gmail.com5079872463

Outcome results