Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis

Relationship Between Elevated Serum Serotonin Levels in Symptomatic Patients With Hyperemezis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01987869

Enrollment

Registered

2013-11-19

Start date

2013-10-31

Completion date

2014-03-31

Last updated

2013-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Markedly Reduced Food Intake, Nausea, Severe Dehydration, Vomiting

Keywords

hiperemesis gravidarum,vomiting,serotonin levels,ketonuria

Brief summary

Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis gravid arum.

Detailed description

The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many theories have been advocated, but to date none of these have been convincing. It has been demonstrated that the nausea and vomiting associated with increased in serotonin liberation. This has provided a rationale for the treatment of these symptoms with specific serotonin antagonists. The aim of this trial was to investigate the possible relationship between hiperemezis gravid arum and serotonin liberation.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

15 Years to 50 Years

Healthy volunteers

Inclusion criteria

* 6-14 week pregnant women * nausea * protracted vomiting * inability to tolerate food intake accompanied by obvious dehydration * severe enough to justify hospitalisation * at least 2+ ketonuria on dipstick urinanalysis.

Exclusion criteria

* with metabolic disorders such as diabet, thyroid

Design outcomes

Primary

Measure	Time frame
serum serotonin levels in hiperemezis gravidarum	6-14week pregnancy

Secondary

Measure	Time frame
ıs there any assosiation between serotonin levels and severity of symptoms in pregnant women with hiperemezis	6-14week pregnancy

Other

Measure	Time frame
ıs there any assosiation between other serum parameters includes estrogen,progesterone and serum beta hcg	6-14week pregnancy

Countries

Turkey (Türkiye)

Contacts

Primary Contacthediye dağdeviren, md

hediyedagdeviren@gmail.com5079872463

Outcome results