Chronic Weight Management
Conditions
Keywords
Overweight, Obese, Weight Management
Brief summary
APD356-A001-402 is a multicenter, double-blind, randomized, parallel-group pilot study of 12-week duration in overweight and obese adults. Approximately 225 subjects will be randomized to one of three treatment arms in a ratio 1:1:1 and will receive the combinations of lorcaserin 10 mg twice daily (BID) plus immediate-release phentermine-HCl 15 mg BID or 15 mg once daily (QD), or lorcaserin alone.
Detailed description
All subjects will take lorcaserin and phentermine-HCl/placebo once in the morning and again in the mid-afternoon. The dosing is timed to help reduce potential insomnia due to phentermine. Subjects in Arm A will take one tablet twice daily of lorcaserin 10 mg in combination with one capsule twice daily of phentermine placebo. Subjects in Arm B will take one tablet twice daily of lorcaserin 10 mg, one capsule of phentermine-HCl 15 mg once daily in the morning, and one capsule of phentermine placebo once daily in the mid-afternoon. Subjects in Arm C will take one tablet twice daily of lorcaserin 10 mg in combination with one capsule twice daily of phentermine-HCl 15 mg. Subjects will be instructed to take lorcaserin tablets and phentermine/placebo capsules concurrently and attempt to remain on a consistent daily schedule. The study will recruit obese (body mass index \[BMI\] greater than or equal to 30 kg/m2) subjects with or without a weight-related comorbid condition (e.g., hypertension, dyslipidemia, or sleep apnea) or overweight (BMI greater than or equal to 27 to 29.9 kg/m2) subjects with at least one weight-related co-morbid condition. At least one third of the subjects will have a BMI of 40 kg/m2 or greater, because there is a high likelihood that this combination therapy will be used by these subjects in medical practice. A lifestyle intervention program, using a 12-week adaptation of the Arena Healthy Lifestyles Program, including diet and exercise counseling, will be implemented for obesity/overweight. Blood sampling will be performed to evaluate the pharmacokinetics (PK) of lorcaserin and phentermine using population PK modeling as well as the potential relationships between exposure to the lorcaserin/phentermine and measures of safety and change from baseline in body weight, using population PK/PD (pharmacodynamics) modeling.
Interventions
DRUGlorcaserin + phentermine placebo
lorcaserin 10 mg BID + phentermine placebo BID
DRUGlorcaserin + phentermine-HCl + phentermine placebo
lorcaserin 10 mg BID + phentermine-HCl 15 mg QD + phentermine placebo QD
DRUGlorcaserin + phentermine-HCl
lorcaserin 10 mg BID + phentermine-HCl 15 mg BID
Sponsors
Eisai Inc.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. BMI is 30 kg/m2 or greater with or without a weight-related comorbid condition (e.g., hypertension, dyslipidemia, sleep apnea), or 27 to 29.9 kg/m2 with at least one weight-related comorbid condition. 2. Ambulatory and able to perform moderate exercise. 3. Male or female subjects between 18 and 60 years at the time of informed consent. 4. Provide written informed consent. 5. Willing and able to comply with all aspects of the protocol.
Exclusion criteria
1. Recent treatment (within 14 days of the Screening Visit and any time prior to randomization) with monoamine oxidase inhibitors (MAOIs). MAOIs have been associated with a risk of hypertensive crisis when used with phentermine. 2. Active or recent history (within 1 month prior to the Screening Visit) of major depression or other major psychiatric disease requiring treatment (i.e., within 1 month of the Screening Visit and any time prior to randomization or thereafter during the study) with prescription medication (e.g., SSRIs, SNRIs, tricyclics, antipsychotics, lithium, Wellbutrin). 3. Use of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) (including buproprion) for reasons other than active psychiatric indications (e.g., migraine, weight loss, smoking cessation) within 1 month prior to the Screening Visit). 4. Medication history that includes use of one or more of the following: 1. Fenfluramine or related derivatives (i.e., dexfenfluramine, norfenfluramine) 2. Agents that have documented correlation with increased incidence of valvulopathy and/or primary pulmonary hypertension (e.g., cabergoline, cyproheptadine, trazodone, nefazodone, amoxapine, mirtazapine, pergolide, ergotamine, methysergide) 5. Recent treatment (i.e., within 1 month of the Screening Visit and any time prior to randomization or thereafter during the study) with over-the-counter (OTC) weight loss products or appetite suppressants (including herbal weight loss agents), or within 6 months and any time prior to randomization or thereafter during the study, with a prescription weight loss drug (e.g., phentermine, phentermine/topiramate, orlistat). 6. Use of St. John's Wort within 1 month prior to the Screening Visit and for the duration of the study. St. John's Wort has been associated with serotonin syndrome when used with another serotonergic drug. 7. Hypersensitivity to sympathomimetic amines or the study drugs. 8. History of stroke, transient ischemic attack, arrhythmias, congestive heart failure, and/or peripheral vascular disease. 9. Recent history of active cardiovascular disease, including chronic stable angina or an unstable angina episode or myocardial infarction within the 3 months prior to the Screening Visit. 10. Uncontrolled hypertension defined as systolic blood pressure greater than or equal to 150 or diastolic blood pressure greater than or equal to 95 on 2 readings taken on different days. Subjects who have uncontrolled hypertension at screening may be re-screened greater than 1 month following initiation or adjustment of antihypertensive therapy. 11. History of or active pulmonary artery hypertension. 12. Severe renal impairment (creatinine clearance less than 30 mL/min, as calculated by the Cockroft-Gault equation based on ideal body weight) or end stage renal disease. 13. History of valve replacement surgery; clinically significant valvular stenosis; history of or active clinically significant valvulopathy (defined as aortic insufficiency of mild, moderate, or severe intensity and/or mitral insufficiency of moderate or severe intensity). 14. History of or active (confirmed fasting glucose greater than 126 mg/dL or hemoglobin A1c \[HbA1c\] greater than ULN \[6.5% at central laboratory\]) diabetes mellitus (type I, II or other) and/or currently taking medications for type I or II diabetes. A past history of gestational diabetes that has resolved is permissible. 15. Glaucoma. 16. Abnormal thyroid stimulating hormone (TSH) laboratory value greater than 1.5 x Upper Limit of Normal (ULN) 17. Hyperthyroidism, including abnormal screening laboratory values with T3 greater than ULN and TSH less than Lower Limit of Normal (LLN), and subjects taking methimazole or propylthiouracil (PTU) and/or beta-blockers for hyperthyroidism. 18. Recent history (within 2 years prior to the Screening Visit) of alcohol or drug/solvent abuse or a positive screen for drugs of abuse at screening. 19. Significant change is smoking habits or tobacco product use within 3 months prior to the Screening Visit. 20. Use of tobacco products (i.e., smokes more than one-half pack of cigarettes per day, or smokes more than 2 cigars per day, or uses 3 or more pinches of smokeless tobacco per day). 21. Surgical procedure for the treatment of obesity (i.e., gastric bypass, gastric banding), even if reversed prior to screening. 22. Planned surgery during the study period that may interfere with completion or compliance with the protocol. 23. A prolonged QT/QTc interval (QTc Bazett's greater than 450 msec) as demonstrated by a repeated electrocardiogram (ECG). 24. Participation in any clinical study with an investigational drug, biologic, or device within 1 month prior to screening. 25. Significant change in diet or level of physical activity within 1 month prior to dosing that in the opinion of the investigator(s) may confound the results of the study. 26. Change in weight of greater than 5 kg within 3 months of screening. 27. Use of a very-low calorie (less than 800/day) liquid weight loss diet within 6 months prior to screening and any time prior to randomization. 28. Eligible male and female subjects participating in a conception process (i.e., active attempt to become pregnant or to impregnate, sperm donation, in vitro fertilization). 29. Females who are lactating or pregnant at Screening or Baseline Visit (as documented by a negative serum or urine pregnancy test with a minimum sensitivity of 25 IU/L or equivalent units of beta-human chorionic gonadotropin \[B-hCG\]). A separate baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the first dose of study drug. 30. All females will be considered to be of childbearing potential unless they are postmenopausal (amenorrheic for at least 12 consecutive months, in the appropriate age group and without other known or suspected cause) or have been sterilized surgically (i.e., bilateral tubal ligation, total hysterectomy, or bilateral oophorectomy, all with surgery at least one month before dosing). 31. Females of childbearing potential must not have had unprotected sexual intercourse within 30 days before study entry and must agree to use a highly effective method of contraception (e.g., total abstinence, an intrauterine device, a double-barrier method \[such as condom plus diaphragm with spermicide\], a contraceptive implant, an oral contraceptive, or have a vasectomized partner with confirmed azoospermia) throughout the entire study period and for 30 days after study drug discontinuation. If currently abstinent, the subject must agree to use a double barrier method as described above if she becomes sexually active during the study period or for 30 days after study drug discontinuation. Females who are using hormonal contraceptives must have been on a stable dose of the same hormonal contraceptive product for at least 4 weeks before dosing and must continue to use the same contraceptive during the study and for 30 days after study drug discontinuation. Females not meeting these criteria will be excluded from the study. 32. Any medical or other condition that in the opinion of the investigator(s) would preclude the subject's participation in a clinical study, such as significantly abnormal laboratory results or any physical or mental condition that prevents compliance with the protocol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of Participants Reporting at Least One of Nine Adverse Events (AEs) of Main Interests That May Related to Serotonergic Reaction | Baseline up to Week 12 (end of treatment) | The nine common serotonergic AEs were headache, dizziness, nausea, fatigue, dry mouth, diarrhea, vomiting, insomnia, and/or anxiety. |
Secondary
| Measure | Time frame |
|---|---|
| Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Baseline up to Week 16 |
| Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Baseline, Weeks 1, 2, 4, 8 and 12 |
| Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Baseline, Weeks 1, 2, 4, 8 and 12 |
| Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | Baseline up to Week 16 |
| Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Baseline and Week 12 (end of treatment) |
| Change From Baseline in Waist to Hip Circumference Ratio at Week 12 | Baseline and Week 12 (end of treatment) |
| Percentage of Participants Who Achieved Greater Than or Equal to (>=) 5 Percent (%) Weight Reduction at Week 12 | Week 12 (end of treatment) |
Countries
United States
Participant flow
Recruitment details
Participants took part in the study at 12 sites in the United States from 30 October 2013 to 03 September 2014.
Pre-assignment details
A total of 344 participants were screened and enrolled, of which 106 were screen failures and 238 were randomized to receive study treatment, out of which 235 participants were treated.
Participants by arm
| Arm | Count |
|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID Participants received lorcaserin 10 mg tablet along with phentermine placebo-matching capsule, orally, BID for 12 weeks. | 78 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD Participants received lorcaserin 10 mg tablet, orally, BID along with phentermine 15 mg capsule, orally, QD, and phentermine placebo-matching capsule, orally, QD for 12 weeks. | 78 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID Participants received lorcaserin 10 mg tablet along with phentermine 15 mg capsule, orally, BID for 12 weeks. | 79 |
| Total | 235 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 | FG002 |
|---|---|---|---|---|
| Overall Study | Adverse Event | 4 | 2 | 8 |
| Overall Study | Lack of Efficacy | 1 | 0 | 0 |
| Overall Study | Lost to Follow-up | 6 | 6 | 9 |
| Overall Study | Other | 1 | 1 | 0 |
| Overall Study | Withdrawal by Subject | 2 | 1 | 3 |
Baseline characteristics
| Characteristic | Lorcaserin 10 mg BID + Phentermine Placebo BID | Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Lorcaserin 10 mg BID + Phentermine 15 mg BID | Total |
|---|---|---|---|---|
| Age, Continuous | 42.5 years STANDARD_DEVIATION 11.02 | 44.8 years STANDARD_DEVIATION 11.08 | 41.2 years STANDARD_DEVIATION 11.69 | 42.8 years STANDARD_DEVIATION 11.32 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 11 Participants | 7 Participants | 6 Participants | 24 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 67 Participants | 71 Participants | 73 Participants | 211 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 1 Participants | 1 Participants | 1 Participants | 3 Participants |
| Race (NIH/OMB) Asian | 0 Participants | 1 Participants | 0 Participants | 1 Participants |
| Race (NIH/OMB) Black or African American | 29 Participants | 26 Participants | 32 Participants | 87 Participants |
| Race (NIH/OMB) More than one race | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 1 Participants | 1 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 2 Participants | 0 Participants | 1 Participants | 3 Participants |
| Race (NIH/OMB) White | 46 Participants | 50 Participants | 44 Participants | 140 Participants |
| Sex: Female, Male Female | 68 Participants | 70 Participants | 62 Participants | 200 Participants |
| Sex: Female, Male Male | 10 Participants | 8 Participants | 17 Participants | 35 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk |
|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 78 | 0 / 78 | 0 / 79 |
| other Total, other adverse events | 50 / 78 | 51 / 78 | 54 / 79 |
| serious Total, serious adverse events | 0 / 78 | 2 / 78 | 1 / 79 |
Outcome results
Primary
Percentage of Participants Reporting at Least One of Nine Adverse Events (AEs) of Main Interests That May Related to Serotonergic Reaction
The nine common serotonergic AEs were headache, dizziness, nausea, fatigue, dry mouth, diarrhea, vomiting, insomnia, and/or anxiety.
Time frame: Baseline up to Week 12 (end of treatment)
Population: The full analysis set included all randomized participants who received at least one dose of the study drug.
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Percentage of Participants Reporting at Least One of Nine Adverse Events (AEs) of Main Interests That May Related to Serotonergic Reaction | 37.2 percentage of participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Percentage of Participants Reporting at Least One of Nine Adverse Events (AEs) of Main Interests That May Related to Serotonergic Reaction | 42.3 percentage of participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Percentage of Participants Reporting at Least One of Nine Adverse Events (AEs) of Main Interests That May Related to Serotonergic Reaction | 40.5 percentage of participants |
Secondary
Change From Baseline in Waist Circumference and Hip Circumference at Week 12
Time frame: Baseline and Week 12 (end of treatment)
Population: The MITT population consisted of all randomized participants who received at least one dose of the study drug and had a Baseline weight measurement and a post-randomization weight measurement. Participants who were evaluable for this measure at given time period were included in the assessment.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Hip Circumference: Change at Week 12 | -2.8 centimeter (cm) | Standard Deviation 8.05 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Waist Circumference: Baseline | 112.2 centimeter (cm) | Standard Deviation 13.82 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Waist Circumference: Change at Week 12 | -3.4 centimeter (cm) | Standard Deviation 7.98 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Hip Circumference: Baseline | 124.1 centimeter (cm) | Standard Deviation 14.3 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Hip Circumference: Baseline | 123.7 centimeter (cm) | Standard Deviation 14.27 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Hip Circumference: Change at Week 12 | -3.6 centimeter (cm) | Standard Deviation 11.29 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Waist Circumference: Change at Week 12 | -4.7 centimeter (cm) | Standard Deviation 10.31 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Waist Circumference: Baseline | 112.2 centimeter (cm) | Standard Deviation 15.09 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Hip Circumference: Baseline | 125.4 centimeter (cm) | Standard Deviation 12.81 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Waist Circumference: Baseline | 114.0 centimeter (cm) | Standard Deviation 12.02 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Waist Circumference: Change at Week 12 | -7.1 centimeter (cm) | Standard Deviation 5.53 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Change From Baseline in Waist Circumference and Hip Circumference at Week 12 | Hip Circumference: Change at Week 12 | -6.2 centimeter (cm) | Standard Deviation 4.41 |
Secondary
Change From Baseline in Waist to Hip Circumference Ratio at Week 12
Time frame: Baseline and Week 12 (end of treatment)
Population: The MITT set included all randomized participants who received at least one dose of the study drug and had a Baseline weight measurement and a post-randomization weight measurement. Participants who were evaluable for this measure at given time period were included in the assessment.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Change From Baseline in Waist to Hip Circumference Ratio at Week 12 | Baseline | 0.91 ratio | Standard Deviation 0.083 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Change From Baseline in Waist to Hip Circumference Ratio at Week 12 | Change at Week 12 | -0.01 ratio | Standard Deviation 0.102 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Change From Baseline in Waist to Hip Circumference Ratio at Week 12 | Baseline | 0.91 ratio | Standard Deviation 0.091 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Change From Baseline in Waist to Hip Circumference Ratio at Week 12 | Change at Week 12 | -0.01 ratio | Standard Deviation 0.044 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Change From Baseline in Waist to Hip Circumference Ratio at Week 12 | Baseline | 0.91 ratio | Standard Deviation 0.084 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Change From Baseline in Waist to Hip Circumference Ratio at Week 12 | Change at Week 12 | -0.01 ratio | Standard Deviation 0.036 |
Secondary
Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12
Time frame: Baseline, Weeks 1, 2, 4, 8 and 12
Population: The Modified Intent-to-Treat (MITT) set included all randomized participants who received at least one dose of the study drug and had a Baseline weight measurement and a post-randomization weight measurement. Participants who were evaluable for this measure at given time period were included in the assessment.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 8 | -2.87 kilogram (kg) | Standard Deviation 2.691 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 4 | -2.27 kilogram (kg) | Standard Deviation 1.823 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 1 | -0.94 kilogram (kg) | Standard Deviation 1.29 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 12 | -3.48 kilogram (kg) | Standard Deviation 3.727 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 2 | -1.56 kilogram (kg) | Standard Deviation 1.547 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Baseline | 105.33 kilogram (kg) | Standard Deviation 20.994 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 8 | -5.76 kilogram (kg) | Standard Deviation 3.711 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 12 | -7.00 kilogram (kg) | Standard Deviation 5.95 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 4 | -3.81 kilogram (kg) | Standard Deviation 2.442 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Baseline | 105.04 kilogram (kg) | Standard Deviation 23.399 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 1 | -1.36 kilogram (kg) | Standard Deviation 1.341 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 2 | -2.43 kilogram (kg) | Standard Deviation 1.566 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 8 | -6.33 kilogram (kg) | Standard Deviation 3.913 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 2 | -2.94 kilogram (kg) | Standard Deviation 1.925 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Baseline | 106.63 kilogram (kg) | Standard Deviation 19.703 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 4 | -4.44 kilogram (kg) | Standard Deviation 2.606 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 12 | -7.55 kilogram (kg) | Standard Deviation 4.725 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Mean Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Change at Week 1 | -1.97 kilogram (kg) | Standard Deviation 1.477 |
Secondary
Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation
Time frame: Baseline up to Week 16
Population: The safety analysis set included all randomized participants who received at least one dose of study drug and had at least one post-baseline safety assessment.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | SAE | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | TEAE | 50 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | AEs leading to study drug discontinuation | 4 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | SAE | 2 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | TEAE | 52 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | AEs leading to study drug discontinuation | 2 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | TEAE | 54 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | AEs leading to study drug discontinuation | 9 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment Emergent Adverse Event (TEAE), Serious Adverse Event (SAE) and AEs Leading to Study Drug Discontinuation | SAE | 1 Participants |
Secondary
Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values
Time frame: Baseline up to Week 16
Population: The safety analysis set included all randomized participants who received at least one dose of study drug and had at least one post-baseline safety assessment. Participants who were evaluable for this measure for given laboratory parameter were included in the assessment.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Phosphorus: low | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Potassium: high | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Total bilirubin: high | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Triglycerides: High | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Gamma glutamyl transferase: high | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Uric acid: high | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Hemoglobin: low | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Lymphocytes: high | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Neutrophils: low | 2 Participants |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | White blood cell (WBC) count: low | 0 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Neutrophils: low | 1 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Phosphorus: low | 1 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Uric acid: high | 0 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Gamma glutamyl transferase: high | 1 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Potassium: high | 3 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | White blood cell (WBC) count: low | 0 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Lymphocytes: high | 0 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Total bilirubin: high | 1 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Hemoglobin: low | 1 Participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Triglycerides: High | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Lymphocytes: high | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Triglycerides: High | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Gamma glutamyl transferase: high | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Uric acid: high | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Neutrophils: low | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Hemoglobin: low | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Phosphorus: low | 0 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | White blood cell (WBC) count: low | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Potassium: high | 1 Participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Number of Participants With Treatment-Emergent Markedly Abnormal Laboratory Values | Total bilirubin: high | 0 Participants |
Secondary
Percentage of Participants Who Achieved Greater Than or Equal to (>=) 5 Percent (%) Weight Reduction at Week 12
Time frame: Week 12 (end of treatment)
Population: The MITT set included all randomized participants who received at least one dose of the study drug and had a Baseline weight measurement and a post-randomization weight measurement.
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Percentage of Participants Who Achieved Greater Than or Equal to (>=) 5 Percent (%) Weight Reduction at Week 12 | 28.2 percentage of participants |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Percentage of Participants Who Achieved Greater Than or Equal to (>=) 5 Percent (%) Weight Reduction at Week 12 | 59.0 percentage of participants |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Percentage of Participants Who Achieved Greater Than or Equal to (>=) 5 Percent (%) Weight Reduction at Week 12 | 70.9 percentage of participants |
Secondary
Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12
Time frame: Baseline, Weeks 1, 2, 4, 8 and 12
Population: The MITT set included all randomized participants who received at least one dose of the study drug and had a Baseline weight measurement and a post-randomization weight measurement. Participants who were evaluable for this measure at given time period were included in the assessment.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 8 | -2.77 percent change | Standard Deviation 2.551 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 4 | -2.18 percent change | Standard Deviation 1.744 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 1 | -0.93 percent change | Standard Deviation 1.212 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 2 | -1.47 percent change | Standard Deviation 1.451 |
| Lorcaserin 10 mg BID + Phentermine Placebo BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 12 | -3.29 percent change | Standard Deviation 3.363 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 4 | -3.68 percent change | Standard Deviation 2.265 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 1 | -1.28 percent change | Standard Deviation 1.234 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 2 | -2.33 percent change | Standard Deviation 1.465 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 8 | -5.54 percent change | Standard Deviation 3.466 |
| Lorcaserin 10mg BID+Phentermine 15mg QD+Phentermine Placebo QD | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 12 | -6.69 percent change | Standard Deviation 5.377 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 12 | -7.23 percent change | Standard Deviation 4.611 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 8 | -6.03 percent change | Standard Deviation 3.722 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 1 | -1.82 percent change | Standard Deviation 1.358 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 4 | -4.20 percent change | Standard Deviation 2.459 |
| Lorcaserin 10 mg BID + Phentermine 15 mg BID | Percent Change From Baseline in Body Weight at Weeks 1, 2, 4, 8, and 12 | Week 2 | -2.75 percent change | Standard Deviation 1.787 |