Type 2 Diabetes Mellitus
Conditions
Keywords
Glycemic control, excess post-exercise oxygen consumption
Brief summary
Four months of interval walking training (IWT) is superior to energy-expenditure matched continuous walking training (CWT) with regards to weight loss and improvements in glycemic control. The reason for this is unclear. One potential explanation for the differential outcome in weight loss is excess post-exercise oxygen consumption (EPOC), which is defined as the elevated oxygen consumption measured during the hours following an exercise bout. A large EPOC means greater energy expenditure which, if energy intake does not change, leads to a greater weight loss. This weight loss may subsequently improve glycemic control * Aim 1: To assess the effect of an acute bout of IWT vs. an acute bout of CWT on glycemic control in type 2 diabetics and to assess mechanisms responsible for differences (if any). It is hypothesised that IWT will be more advantageous for improving glycemic control. * Aim 2: To examine the effect of an acute bout of IWT vs. an acute bout of CWT on EPOC. It is hypothesised that IWT will produce an EPOC of larger magnitude than CWT.
Interventions
BEHAVIORALInterval Walking
BEHAVIORALContinuous walking
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diabetes mellitus, type 2
Exclusion criteria
* Smoking * Pregnancy * insulin dependence * Contraindication to physical activity (as judged by medical history and screening) * Evidence of thyroid, liver, lung, kidney or heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glycemic control | Will be assessed immediately after the intervention using a mixed meal tolerance test (duration: 5 hours) followed by continuous glucose monitoring (duration: 48 hours). | Glycemic control will be assessed after a one hour specific exercise intervention (control/continuous walking/interval walking) in a controlled setting (a mixed meal tolerance test). Moreover, glycemic control will be assessed during the following 2 days in a free-living environment, using continuous glucose monitoring systems. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Excess post-exercise oxygen consumption (EPOC) | Will be assessed immediately after the intervention using a ventilated hood (duration: 5 hours). | EPOC will be assessed during the hours following the before-mentioned specific exercise bouts using the indirect calorimetry ventilated hood technique. |
Countries
Denmark
Outcome results
None listed