Transversus Abdominis Plane (TAP) Block for Post Caesarian Pain

Phase 3 Study Comparing Transversus Abdominis Plane Block After Caesarian Section Usin Bupivacaine 0.5% vs. Bupivacaine 0.25% vs. Placebo (Normal Saline).

Status

Withdrawn

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01986049

Acronym

TAPBlock

Enrollment

Registered

2013-11-18

Start date

2013-02-28

Completion date

2013-08-31

Last updated

2021-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstetrical Complications From Sedation During Parturition

Brief summary

Adding TAP block with Bupivacaine may decrease the use of PCA bolus use after caesarean section for pain relief.

Detailed description

Participants in the study will be randomized to TAP block with 0.5% or 0.25% bupivacaine or with placebo (normal saline). The number of PCA bolus used within 24 hours post cesarean section will be compared between the groups.

Interventions

DRUGBupivicaine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

Healthy pregnant (ASA II) patients presenting for planned Cesarean delivery at New York Methodist Hospital under combined spinal epidural anesthesia

Exclusion criteria

* They are unable or are unwilling to take part in the study * They have a history of allergy to any of the medications to be used in the study * They have a history of drug abuse or chronic pain or opioid use * They weigh less than 60kg * They have a multiple gestation, placental disease, preeclampsia other disease of pregnancy * They have a contraindication to neuraxial anesthesia (i.e., bleeding problems, bacteremia, etc.) * They are unable to understand instructions or questions related to the study * ASA III or IV

Design outcomes

Primary

Measure	Time frame	Description
Transversus Abdominis Plane (TAP) Block for Post Caesarean Pain	The first post operative 24 hours	In Patient Controlled analgesia (PCA) system, the patient receives a preset dose of morphine by pressing a button on a computerized pump that is connected to an IV catheter. With PCA the patient may receive a small continuous flow of morphine and add more morphine as needed to provide a more constant level of comfort. In this study, we will compare the number of PCAs used by the participants in each arm

Secondary

Measure	Time frame	Description
Decrease in the pain score as measured by Visual Analog Scale (VAS)	The first post operative 24 hours	Visual Analog Scale (VAS) is a numeric scale to measure the pain intensity from 0 to 10, where 0 = no pain, (1-3) = mild pain, (4-6) = moderate pain, and (7-10) = severe pain. The worst imaginable pain = 10

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026