Interstitial Cystitis
Conditions
Keywords
Biomarkers
Brief summary
The purpose of this study is to evaluate efficacy of biomarker in patient with interstitial cystitis/painful bladder syndrome
Detailed description
This is a observational study
Interventions
None listed
Sponsors
Asan Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 1\) must have experienced bladder pain, urinary urgency and urinary frequency, for at least 6 months prior to entry into the study 2) Pain VAS ≥4 3) O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) symptom and problem ≥ 12( and pain ≥2, and nocturia ≥ 2) 4) PUF score ≥ 13 5) cystoscopic record within 2 years
Exclusion criteria
1. Patients who are pregnancy or, childbearing age without no contraception 2. Patients with voided volume \<40 or, \> 400ml 3. Patients with microscopic hematuria, (≥1+ in dipstick), If not excluded that no evidence of neoplastic tumor examination 4. Patients with urine culture showing evidence of urinary tract infection 1month prior to the study 5. Accompanied medical problem below * Tuberculosis in urinary system * Bladder cancer, urethral cancer, prostate cancer * Recurrent cystitis * anatomical disorder 6. Patients had prior surgery (eq, bladder augmentation, cystectomy 7. Patients with neurologic disorder 8. Patients with indwelling catheter or intermittent self-catheterization 9. Patients with psychologic problem
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare of expression of the biomarker such as APF, HB-EGF, MCP-1 among the Hunner's ulcer interstitial cystitis and non-ulcer interstitial cystitis and control groups | 1month | To compare of expression of the biomarker such as APF, HB-EGF, MCP-1 among the Hunner's ulcer interstitial cystitis and non-ulcer interstitial cystitis and control groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To compare of changes voiding parameters after bladder biopsy between Hunner' ulcer group and non-ulcer group | 1 month | To compare of changes voiding parameters after bladder biopsy between Hunner' ulcer group and non-ulcer group |
| TO compare of change of scores of questionnaires such as O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q), Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF), Visual Analogue Scale (Pain) between Hunner's ulcer group and non-ulcer group | 1month | TO compare of change of scores of questionnaires such as O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q), Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF), Visual Analogue Scale (Pain) between Hunner's ulcer group and non-ulcer group |
Countries
South Korea
Outcome results
None listed