Patients Undergoing Elective Craniotomy
Conditions
Keywords
Desflurane, Propofol, Total intravenous anesthesia, Neurosurgery
Brief summary
Since neurological testing during neurosurgery, such as somato-sensory evoked potentials, motor-evoked potentials, auditory evoked potentials and visual evoked potentials are well maintained their wave-form reactivity with total intravenous anaesthesia technique better than inhalational anesthetic techniques, the standard anesthesia method for neurosurgery is usually total intravenous anaesthesia technique. Nonetheless, after finishing recording the evoked potential responses during surgery, facilitation of recovery from general anesthesia is getting important, because the real neurological physical examination is much more sensitive than above electrical evoked potentials to evaluate the results of surgical operation. We propose to evaluate the recovery parameters after conversion from total intravenous anaesthesia technique to Desflurane anesthesia during long term neurosurgery procedures. The conversion will be initiated upon completion of the neurophysiological electric evoked potentials assessment. Based on the pharmacological properties of desflurane, we hypothesize that recovery after conversion to Desflurane will be faster compared to recovery after total intravenous anaesthesia alone.
Interventions
DRUGPropofol
DRUGDesflurane
Sponsors
Baxter Healthcare Corporation
Tokyo Women's Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing elective craniotomy * American Society of Anesthesiology Physical Status Ⅰ, II and III * Age: between 20 to 65 years * Sex: male or female * Patients who are postmenopausal or surgically sterilized * Expected Operation time is longer than 4 hours.
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time from the discontinuation of anesthesia to extubation | Patients will be followed in the operation room, an expected average of 30 minutes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time from the discontinuation of anesthesia to eye opening | At the end of surgery, duration time from the discontinuation of anesthesia to the eye opening will be measured, averaged expected time is 30 minutes | — |
| Cognitive function | Up to 24 hours | Cognitive function will be measured by Mini-Mental state examination at baseline (preoperatively) 5 minutes and 24 hours after extubation. Postoperative recovery function will be also measured by Post-operative Quality Recovery Scale (PQRS scale) at 5 minutes and 24 hours after extubation. |
| Time from the discontinuation of anesthesia to orientation | Up to 24 hours | Time from the discontinuation of anesthesia to orientation (State name, state the date of birth) |
Other
| Measure | Time frame |
|---|---|
| Length of ICU stay | Patients will be followed for the duration of intensive care unit stay, an expected average of 1 week |
Countries
Japan
Contacts
Primary ContactMakoto Ozaki, Ph.D
Outcome results
None listed