Characterisation of Circadian Rhythm in Autistic Spectrum Disorder

Characterisation of Circadian Rhythm in Autistic Spectrum Disorder : a Clinical, Biochemical and Genetic Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01984944

Enrollment

Registered

2013-11-15

Start date

2009-10-31

Completion date

2013-08-31

Last updated

2014-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autistic Disorder

Keywords

circadian rhythm

Brief summary

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.

Interventions

OTHERAutistic functional exploration

* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer

OTHERControl functional exploration

* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

6 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients with autistic spectrum disorders * At least 6 years old * Membership of a social security scheme * Informed consent signed by the patient or both holders of parental authority if the subject is a minor, or by a guardian if the subject is under guardianship

Exclusion criteria

* Recent sleep symptoms * Incapacity to keep rested for 24 hours

Design outcomes

Primary

Measure	Time frame
Urinary sulfatoxymelatonin secretion	The determination will be performed at 14 days ( child)

Secondary

Measure	Time frame
Core body temperature rhythm	The determination will be performed at 5 days (adult)
Circadian rhythms assessed with actometer	The determination will be performed at 14 ( child) and 21 days (adult)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026