Infant, Premature, Diseases
Conditions
Brief summary
Alterations to microvascular blood flow in premature infants, are known to contribute to several major disease entities. The optically-measured tissue blood flow, to determine tissue perfusion that can be use to detect blood loss.
Detailed description
The researchers want to use optical technologies to non-invasively detect blood flow that can tell the onset of blood loss. The research can measure blood flow in stable premature infants in the Neonatal Intensive Care Unit over the duration of several weeks. The technologies are Laser Speckle Imaging and Diffuse Optical Spectroscopy. Laser Speckle Imaging non-contact imaging technology, is sensitive to blood flow in superficial tissues. Diffuse Optical Spectroscopy, a probe-based contact technology like pulse oximetry, measures hemoglobin concentrations and states deeper below the skin surface.
Interventions
DEVICELaser Speckle Imaging and Diffuse Optical Spectroscopy
Laser Speckle Imaging and Diffuse Optical Spectroscopy
Sponsors
Beckman Laser Institute University of California Irvine
University of California, Irvine
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 1 Months
Healthy volunteers
Yes
Inclusion criteria
* premature infants born or transferred to neonatal intensive care unit with a gestational age of 28-35 weeks
Exclusion criteria
* NONE premature infants born or transferred to neonatal intensive care unit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Normal Blood flow in premature infant | up to 4 weeks |
Countries
United States
Outcome results
None listed