Urethral Stricture
Conditions
Brief summary
The analysis of the long-term outcomes and quality-of-life parameters after urethral reconstruction surgery.
Detailed description
Urethroplasty is the surgical repair of a urethral stricture. Depending on the location, severity and length of the stricture, various techniques can be performed. The first procedure consists of the excision of the stenotic segment and end-to-end anastomosis. Other procedures consist of widening the urethra with buccal mucosa as free graft or with vascularized (genital) skin flaps. The results of these techniques have been described in prospective cohort studies, but to date there is little good data about the functional outcome and quality-of-life with longer follow-up after this surgery. The purpose of this study is to prospectively follow patients for functional outcome parameters and quality-of-life to obtain long-term information concerning these surgeries.
Interventions
PROCEDUREend-to-end urethroplasty
PROCEDUREsubstitution urethroplasty (buccal mucosa)
PROCEDUREsubstitution urethroplasty (pedicled skin flap)
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* male * urethral stricture surgery * informed consent
Exclusion criteria
* loss of follow-up * not willing to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality Of Life: change from baseline (=preoperative value) | 6m, 1y, 2y, 3y, 4y | Validated questionnaires (patient reported outcome measures) concerning general discomfort, micturition problems, erections, and the impact of those problems on their social life. * International Prostate Symptom Score - Quality of Life questionnaire (IPSS-QOL) * International Consultation of Incontinence - Lower Urinary Tract Symptoms Quality of Life questionnaire (ICIQ-LUTSQoL) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional outcomes: micturition: change from baseline (=preoperative value) | 6m, 1y, 2y, 3y, 4y | Validated questionnaires * International Consultation of Incontinence - Lower Urinary Tract Symptoms Quality of Life questionnaire (ICIQ-LUTSQoL) * Urogenital Distress Inventory short form (UDI-6) |
| Functional outcomes: erection: change from baseline (=preoperative value) | 6m, 1y, 2y, 3y, 4y | Validated questionnaires \* International Index of Erectile Dysfunction (IIEF) |
Countries
Belgium
Outcome results
None listed