Adductor Canal Block and Effect of 10 Versus 30 ml Ropivacaine on Muscle Strength: a Randomized Study in Healthy Volunteers

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01981746

Enrollment

Registered

2013-11-11

Start date

2013-11-30

Completion date

2013-12-31

Last updated

2014-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers, Muscle Strength

Keywords

adductor canal block, healthy volunteers, US-guided peripheral nerve block, lower limb

Brief summary

To investigate whether reducing the volume (30 versus 10 ml) ropivacaine injected can reduce the number of subjects with impaired muscle strength following adductor canal block. We hypothesized that adductor canal block with 10 ml 0.1% ropivacaine preserves quadriceps strength compared with an adductor canal block with 30 ml.

Interventions

PROCEDUREAdductor canal block with ropivacaine 0.1%

US-guided adductor canal block

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* 18-30 years * Men * ASA 1 * Body Mass Index 18-25

Exclusion criteria

* Allergy to study medication * Earlier trauma or surgery to the lower limb * Diabetes Mellitus

Design outcomes

Primary

Measure	Time frame	Description
Number of subjects with reduced quadriceps strength	0.5 to 6 hours post block	The difference between the two volumes in number of subjects experiencing a reduction in quadriceps muscle strength by more than 25% from baseline in two consecutive assessments.

Secondary

Measure	Time frame	Description
Quadriceps strength in percentage of baseline	2, 3 and 4 hours post block	The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle, assessed as percentage of the baseline value.
Quadriceps strength calculated as AUC	30 minutes to 6 hours post block	The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle calculated as area under the curve (AUC)
Modified 30-second Chair Stand test	2 and 4 hours post block	The difference between the pre block value and the post block value in the modified 30-second Chair Stand test performed on one leg, between the two volumes.
VAS pain scores during warmth stimulation	Mean value for the periode 30 minutes - 6 hours post block	The difference between the two volumes in VAS pain score during warmth stimulation.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026