Subthalamic Nucleus Connectivity in Parkinson's Disease With Ultra-high Field Magnetic Resonance Imaging

Ultra-high Field Imaging of the Cortico-striato-subthalamic Functional and Structural Connectivity to Improve Deep Brain Stimulation Surgery in Parkinson's Disease Patients

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01981577

Enrollment

Registered

2013-11-11

Start date

2014-04-30

Completion date

Unknown

Last updated

2016-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Keywords

Parkinson Disease, Subthalamic Nucleus, Ultrahigh field Magnetic Resonance imaging, Functional connectivity, Structural connectivity

Brief summary

The purpose of this study is to investigate the segregation of the subthalamic nucleus into its motor and non-motor regions in patients with Parkinson's disease and healthy controls with the aid of ultra-high field magnetic resonance imaging.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Both groups: * Mental competence Group 1: * Parkinson's disease patients scheduled for deep brain stimulation surgery Group 2: * Age and gender matched volunteers

Exclusion criteria

Both groups: * Head injury * Stroke * Other neurological diseases other than Parkinson's disease * Metallic prostheses or pacemaker in the subject's body or other contra indications for MRI Group 1: * Inability to abstain from dopaminergic drug use Group 2: * Parkinson's disease * Use of medication affecting the central nervous system

Design outcomes

Primary

Measure	Time frame	Description
Voxels of the subthalamic nucleus that are structurally or functionally connected to the motor cortex.	One measurement, consisting of 1 MRI scan of 1 hour	Two brain areas are said to be structurally connected if they are connected by fiber tracks computed from diffusion weighted MRI data. Two brain areas are said to be functionally connected if they show statistically significantly correlated resting state functional MRI signals.

Secondary

Measure	Time frame	Description
Strength of the structural and functional connectivity between the subthalamic nucleus and the motor cortex.	One measurement, consisting of 1 MRI scan of 1 hour	Strength of the structural connectivity is defined as: fractional anisotropy along computed fiber tracks between the subthalamic nucleus and the motor cortex. Strength of the functional connectivity is defined as: height of the correlation between the resting state functional MRI signals in the subthalamic nucleus and the motor cortex.
Brain areas structurally and functionally connected to the stimulation zone of the optimal electrode of operated Parkinson's patients.	One measurement, consisting of 1 MRI scan of 1 hour	This results in a list with brain structures that are functionally and/or structurally connected to the stimulation zone.
Brain areas that show an activation pattern measured with functional magnetic resonance imaging, that is correlated to a motor task.	One measurement, consisting of 1 MRI scan of 1 hour	This results in a list of brain areas that are related to the motor task.

Countries

Netherlands

Contacts

Primary ContactBirgit R Plantinga, MSc.

B.R.Plantinga@tue.nl+31 43 3881033

Outcome results