Light; Therapy, Complications
Conditions
Brief summary
We are evaluating the effect of methylene blue and visible light activation on the microbiome of the skin.
Detailed description
Antiseptics are routinely utilized to prevent infections of vascular catheters. We are evaluating the addition of methylene blue and light activation on skin to determine whether this inexpensive and non-toxic treatment can decrease skin pathogens and prevent blood stream infections of long-term vascular catheters. This is a pilot study of normal volunteers to determine the effect on the microbiome of the addition of methylene blue and light activation on antiseptic-treated skin.
Interventions
PROCEDUREMethylene blue and light treatment
Methylene blue and light treatment for 17 minutes are done twice over 1 week intervals.
Sponsors
Massachusetts General Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal individuals without skin problems
Exclusion criteria
* Smokers * Diabetics * Atopic dermatitis * G-6-PD deficiency * Eczema * Other skin conditions * Allergies to methylene blue or chlorhexadine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the skin microbiome after methylene blue treatment | 1 week | We compared the two arms of each subject --one arm treated with chloraprep and a biopatch \[routine treatment of skin\] to the routine treatment with the addition of methylene blue spray and light activation. The microbiome of both skin areas were assessed before and after the routine treatment and the treatment with the addition of methylene blue therapy; |
Outcome results
None listed