Liver Fibrosis
Conditions
Keywords
Liver fibrosis, Elastography, MR Elastography, Quantitative imaging
Brief summary
Liver fibrosis has been considered as irreversible change. However, recent study showed that early stage liver fibrosis could be reversible and a lot of new drugs are now developing or developed including anti-viral treatment. Liver biopsy is considered as golden standard for the evaluation of liver fibrosis. But biopsy specimen through biopsy only consists of 1/50000 of the whole liver and heterogeneity of liver fibrosis, accurate diagnosis of liver fibrosis is still challenging. Furthermore, its invasive nature, repeated biopsy is practically almost impossible. Hence, non-invasive diagnosis of liver fibrosis is important. In this study we hypothesized that multi-parametric MR imaging including MR elastography, conventional DWI, and IVIM can predict changes of liver stiffness after anti-viral therapy in patients with chronic liver disease. We will enroll 60 biopsy-proven patients and perform multi-parametric MR imaging at the enrollment and one year later to evaluate changes in quantitative values in MR.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients who had chronic hepatitis * Patients who underwent liver biopsy within 6 months * Patients older than 18 years old
Exclusion criteria
* patient who had pregnancy * patient 18 or below 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in quantitative values measured from Multi-parametric MRI before and after anti-viral treatment | 1 year after enrollment | Elasticity, conventional ADC value, IVIM ADC value, T2\* value, T1 rho value will be compared before and after anti-viral treatment |
Countries
South Korea
Contacts
Primary ContactMi-Suk Park, MD
Outcome results
None listed