Genome-wide Study for Disease Susceptibility Gene(s) in Patients With Hand Osteoarthritis

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01981265

Enrollment

100

Registered

2013-11-11

Start date

2012-02-29

Completion date

2016-11-30

Last updated

2013-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand Osteoarthritis

Brief summary

This is a case-control study involving one medical center and one research institute to develop a data-set containing a minimum of 100 osteoarthritis cases, minimum of 100 independent controls of similar gender ratio and a minimum of 100 disease controls (cases with hip and/or knee OA) to associate DNA sequence (allelic) variations in candidate genes with osteoarthritis phenotypes. This study is intended to begin at the Institute of Biomedical Sciences at Academia Sinica (which includes National Genotyping Center (NGC) and National Clinical Core (NCC)), National Taiwan University Hospital.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to 75 Years

Healthy volunteers

Yes

Exclusion criteria

1. Patients with the following diseases will be excluded：Rheumatoid arthritis, Gout arthritis, Psoriatic arthropathy, Hypertrophic osteoarthropathy, Hypermotility syndrome, Hemochromatosis, Post-traumatic OA, Other secondary-form OA and Lupus. 2. The individual is excluded if the hand X-rays show MCP changes compatible with hemochromatosis. The site then is obligated to measure fasting transferrin saturation (FE/TIBC ratio) and if \>55%, the individual is excluded. 3. Have more than 3 swollen MCP joints equal to, or greater than KL grade 2. 4. Be unable to give informed consent. 5. One cannot participate in this study if other members of his or her immediate family have already been recruited (Only one person from each family can participate in the study).

Design outcomes

Primary

Measure	Time frame	Description
Hand Osteoarthritis related gene expression assay	4 years	The sample was collected from the patient who suffered from osteoarthritis of finger joints, espcially DIP joint. The operation was perfomed due to arthrodesis procedure. So we set the outcome measurement goal for the arthrodesis successful rate.

Countries

Taiwan

Contacts

Primary ContactChih-Hao Chang

mike920@gmail.com886-2-23123456

Backup ContactMing Ta Michael Lee

mikelee@ibms.sinica.edu.tw886-2-27899077

Outcome results