The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Pilot Study in Normo-responder IVF Patients

The Exogenous Progesterone Free Luteal Phase After GnRHa Trigger - a Randomized Controlled Pilot Study in Normo-responder IVF Patients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01980680

Acronym

GnRHa trigger

Enrollment

Registered

2013-11-11

Start date

2014-12-31

Completion date

2020-05-31

Last updated

2020-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Brief summary

After hCG trigger a large amount of exogenous progesterone is used for luteal phase support in many countries until 10th week of gestation. Instead we suggest the use of two small doses of hCG after the trigger during the early luteal phase after GnRHa trigger, promoting the endogenous progesterone production from the corpora lutea (CL).

Interventions

DRUGhCG

DRUGProgesterone and Estradiol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Age between 20 and 40 * Normal menstrual cycles: 25-34 days * Oligomenorrhea/amenorrhea or polycystic syndrome (defined according to the Rotterdam criteria 2004) * BMI \>18 and \<35 kg/m2

Exclusion criteria

* Patients with \>14 follicles on day of trigger * Previous hyperresponse with OHSS development * Previous low response (less than 3 oocytes on a high dose of FSH stimulation) * Endocrine disorders

Design outcomes

Primary

Measure	Time frame
Ongoing pregnancy rate per patient	10th week of gestation.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026