Delirium, Electroencephalographic Alterations and Cortical Spreading Depression (CSD) in Critical Illness

Delirium, Electroencephalographic Alterations and Cortical Spreading Depression in Critical Illness

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01980251

Enrollment

102

Registered

2013-11-08

Start date

2013-10-31

Completion date

2015-09-30

Last updated

2016-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium

Keywords

Delirium, electroencephalography, CSD

Brief summary

Delirium in the intensive care unit is an acutely developed brain dysfunction affecting up to 80 % of patients. It is associated with significantly increased morbidity and mortality during admission and post-discharge. The mechanism behind the condition is poorly understood but assumably multifactorial, and the purpose of this study is to investigate the pathophysiology further.

Detailed description

The pathophysiology behind delirium in critical illness is not clarified but assumed to involve inflammation, changes in cerebral perfusion and neurotransmission, sleep deprivation and the use of i.e. sedatives. Cortical spreading depression is a phenomenon occuring in critically ill patients with acute cerebral trauma and likely associated with significant secondary neuron damage. The hypothesis is that 1. Delirium in critically ill patients without acute cerebral damage is a clinical manifestation of cortical spreading depression and can be recorded in a noninvasive direct current-electroencephalography 2. Electroencephalographic alterations or potentially specific signatures occur in delirium and thus, delirium can be predicted by recording continuous alternate current electroencephalography on admission in an ICU

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* expected admission in the ICU \>24 hours

Exclusion criteria

* Cerebral trauma \<6 months * existing delirium * severe dementia

Design outcomes

Primary

Measure	Time frame
The occurence of electroencephalographic alterations and potential electroencephalographic signatures prior to and during delirium in the ICU	7 days

Secondary

Measure	Time frame
The occurence of cortical spreading depression in noninvasive direct current-EEG in critically ill patients without acute cerebral trauma	Cortical spreading depression in the ICU

Other

Measure	Time frame
Comparing electroencephalographic and electrocortical recordings in neurointensive care	Delirium - a clinical manifestation of cortical spreading depression?

Countries

Denmark

Outcome results