Cognitive Diseases
Conditions
Keywords
Alzheimer, cognitive diseases, Ankle-to-brachial index
Brief summary
The main objective of this study is to look for the interest forecast of the IPS as infra-clinical cardiovascular marker in the prediction of a change of the cognitive functions (MCI) at the elderly of 70 and more years old without clinical cardiovascular pathology.
Interventions
Sponsors
University Hospital, Limoges
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* free-living community-dwelling men and women aged ≥ 70 years, * subjects free of clinical CVD related to atherosclerosis * preserved basic activities of daily living (ADL = 6) * without cognitive impairment (MMSE≥24)
Exclusion criteria
* subjects with clinical history of any of the following CVD diseases : coronary artery disease (angina, myocardial infarction, coronary revascularization), cerebrovascular disease (stroke, TIA, carotid revascularization), clinical peripheral artery disease (claudication, critical limb ischemia) * subjects with neurodegenerative, locomotor and ophtalmological diseases unable to perform the cognitive tests * subjects unable to give written informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incident MCI according to the following criteria | one time point | (1) cognitive complaint (self-reported and/or informant) ; (2) preserved basic activities of daily living (ADL) ; (3) cognitive impairment (not normal for age and education) or decline in cognition evidenced by performance on objective cognitive tasks defined as a test performance \<1.0 standard deviations below the mean of the reference group ; (4) preserved general cognitive functioning and (5) absence of dementia. |
Countries
France
Outcome results
None listed