General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01978717

Enrollment

Registered

2013-11-07

Start date

2011-09-30

Completion date

2012-09-30

Last updated

2013-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Neoplasms

Keywords

Anesthesia, T-helper, MDSCs, Colorectal cancer, Fast track

Brief summary

The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.

Interventions

PROCEDUREepidural anesthesia

PROCEDUREgeneral anesthesia

Patients received general anesthesia for surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

51 Years to 65 Years

Healthy volunteers

Inclusion criteria

* patients with Colorectal Cancer(CRC); * subjected to the Fast-Track processing of surgery; * between 18 and 75 years old.

Exclusion criteria

* American Society of Anesthesiologists(ASA) grade \> III; * BMI \> 30; * a history of abdominal surgery, endocrine or immune system dysfunction; * recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month; * previous contraindication to epidural anesthesia.

Design outcomes

Primary

Measure	Time frame	Description
The changes of peripheral immune cells and cytokines	within the first 5 days after surgery	The changes of peripheral subtype of T-helper, myeloid-derived suppressor cells(MDSCs) and cytokines

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026