Acute Kidney Injury, The Changes of Endothelium-dependent Arterial Dilation, The Changes of Plasma Creatinine, The Changes of Plasma Free Radicals
Conditions
Keywords
Type 2 diabetes, Nephropathy, Contrast medium, Alpha lipoic acid
Brief summary
Contrast-induced acute kidney injury (CIAKI) is a major complication with adverse outcomes after contrast media injection. Although the risk of developing CIAKI is low in patients with normal renal function, it is dramatically higher in patients with conditions such as diabetes mellitus (DM) or chronic kidney disease (CKD). More recently, our data showed that contrast agents can induce endothelial dysfunction partially via free radicals in diabetes. Therefore, strategies to prevent CIAKI and endothelial dysfunction in DM patients with CKD are urgently needed. Alpha-lipoic acid and its reduced form, dihydrolipoate, are potent antioxidants. We hypothesized that alpha lipoic acid can prevent the contrast-induced acute kidney injury and endothelial dysfunction in type 2 diabetes.
Interventions
DRUGAlpha lipoic acid
Sponsors
Xiang Guang-da
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* type 2 diabetes * nephropathy (stage 3 and 4)
Exclusion criteria
* recive alpha lipoic acid * type 1 diabetes * nephropathy (stagte 1, 2 and 5) * hypersensitivity to contrast media * IV heart failure * lactic acidosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Contrast induced acte kidney injury | 6 months |
| The changes of endothelium-dependent arterial dilation before and after contrast administrated | 6 months |
Countries
China
Contacts
Primary ContactXiang Guangda, MD
Outcome results
None listed