Healthy
Conditions
Keywords
Impedance cardiography, bioimpedance, spectroscopy, extracellular resistance, body composition, hemodynamics, alcohol
Brief summary
Examination if the bioimpendanz measurement can be used for the determination of the alcohol content in human blood. Furthermore the blood alcohol content (BAC) will be estimated by an official breathalyzer and one blood test.
Detailed description
In this clinical trail it will be analyzed, if it is possible to assess the blood alcohol content (BAC) with the bioimpedance devices (SFB7, ImpediMed; Nicomo). This technology is non-invasive an can be measured by using conductive electrodes, capacitive electrodes or inductive measurement systems. The BIS-values will be compared with an official breathanalyzer (Alcotest 7110 Evidential MK III, Dräger, Lübeck, Germany). Furthermore one blood sample will be taken and analyzed with the ADH method as the current gold standard at the end of the trail.
Interventions
DEVICEbioimpedance mesurements
Bioimpedance measurements were conducted with a BIS device (SFB7, ImpediMed, Pinkeba, Australia) covering a frequency range between 5 kHz and 1 MHz and an ICG device (Niccomo, medis, Ilmenau, Germany)
Sponsors
RWTH Aachen University
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male subjects * able to give informed consent * Inconspicuous laboratory and drug screening
Exclusion criteria
* electrophobica * alcoholphobica, -allergy * metallic ans / or electric implants * underage persons * interactively medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bioimpedance measurements | 4 hours | Evaluation if the bioimpedance measurements can be used to verify and quantify the alcohol content in human blood. Bioimpedance measurements will be conducted with the BIS device (SFB7, ImpediMed) covering a frequency range between 5 kHz and 1 MHz and an ICG device (Niccomo,medis) operating at. The whole-body and hand-to-hand bioimpedance will be analyzed. Extracellular resistance (Re), intracellular resistance (Ri) and capacitive effects (Cm) are calculated by using the Cole model Grimnes (2000). |
Countries
Germany
Outcome results
None listed