The Breathe Light Study

The Breathe Light Study: Validation of Carbon Stable Isotope Ratio in Breath as an Indicator of Energy Balance and Substrate Utilization

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01976455

Enrollment

Registered

2013-11-05

Start date

2013-10-31

Completion date

2016-11-30

Last updated

2022-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Over-eating

Keywords

obesity, carbon13, over-eating, metabolic chamber, room calorimeter

Brief summary

The purpose of this study is to develop a novel, non-invasive method that will provide personalized feedback during dietary interventions as a marker for compliance.

Interventions

OTHER20% fewer calories

OTHER40% fewer calories

Study design

Observational model

CASE_CROSSOVER

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* 18 to 65 years old * Overweight (BMI 25-40 kg/m2)

Exclusion criteria

* Metabolic or cardiovascular abnormalities (diabetes, uncontrolled hypertension, etc.) * Gastrointestinal disorders * Disease that affects macronutrient utilization * Medication that affects macronutrient utilization * Allergies to foods to be utilized in the study (including but not limited to lactose intolerance/milk allergy) * Use of nutritional/sport supplements * Pregnant or currently trying to become pregnant

Design outcomes

Primary

Measure	Time frame	Description
Increase in breath Carbon 13 with overconsumption of calories	11 days	A period of positive energy balance following one of negative energy balance increase breath Carbon13.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026