Pulmonary Disease, Chronic Obstructive (COPD)
Conditions
Brief summary
Hypothesis: A commercial e-nose (Cyranose 320) is able to detect specific breathprints from patients with COPD and bacterial infection
Detailed description
Thirty to 50% of COPD patients have airway colonization with potentially pathogenic bacteria. This is associated with worse prognosis. Currently, diagnosis of bacterial colonization relies mainly upon quantitative sputum culture. However, this method lacks good sensitivity. The electronic nose is a novel device made up of nanosensors capable of detecting specific volatile organic compounds (VOCs). OBJECTIVES: Main 1) To assess the usefulness of the electronic nose in the diagnosis of bacterial colonization in COPD. Secondary 1) To define the VOCs pattern associated with bacterial colonization. 2) To study the pattern of pulmonary and systemic inflammation associated with bacterial colonization as well its relationship with the aforementioned VOCs patterns.
Interventions
DEVICEenose
Sponsors
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* COPD patients
Exclusion criteria
* Exacerbation in the last 4 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Breathprint in exhaled breath from patients with COPD | Day 1 | Breathprints will be assessed by discriminant analysis on principal component reduction, resulting in cross-validated accuracy values |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Breathprint in exhaled breath from COPD patients with bacterial colonization | Day 1 | Breathprints will be assessed by discriminant analysis on principal component reduction, resulting in cross-validated accuracy values |
Countries
Spain
Outcome results
None listed