Exposure to Pollution, Nasal Obstruction
Conditions
Keywords
motorcyclist, nasal mucociliary clearance, physical therapy
Brief summary
Professionals working in polluted areas may present increased clinical airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and bronchiolitis, and instillation the nasal cavity with saline has been used to reduce nasal inflammation in rhinitis and sinusopathies. The aim of this study was to assess the effects of RRC and RCC combined with saline (RRC+S) on nasal mucociliary clearance (MCC), mucus surface property, cellularity and airways symptoms in professional motorcyclists.
Detailed description
Male motorcyclists (mean age 36 years) were recruited and randomly assigned to RRC or RRC+S. Subjects were assessed at baseline and 15 days after interventions for saccharin test, mucus contact angle, cellularity in nasal lavage and airways symptoms with the use of SNOT-20 questionnaire. Data were analyzed by two-way ANOVA for repeated measures with Bonferroni´s correction. A passive monitoring-system of nitrogen dioxide was used to assess the individual air pollution exposure along the study period. The association between nitrogen dioxide and the airways outcomes was analyzed by Spearman correlation test.
Interventions
OTHERrhinopharyngeal retrograde clearance (RRC)
The rhinopharyngeal retrograde clearance is a respiratory physical therapy technique that uses a forced inspiratory maneuver to clear the nasopharynx with the aid of saline instillation
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Professional motorcyclists aged 18 years to 45 years * Minimum of one year in that occupation * Agreement with the written informed consent
Exclusion criteria
* Smokers * Inability to understand and to follow commands * Previous nasal surgery * Respiratory infection in the previous 30 days
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Saccharine transit time test (STT) | 15 days | To measure nasal mucociliary clearance. Subjects were asked to report the first perception of a sweet taste after 25 mg of saccharine powder was deposited in the free airflow nostril. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mucus surface property | 15 days | The contact angle of nasal mucus was measured. |
Other
| Measure | Time frame | Description |
|---|---|---|
| SNOT-20 | 15 days | A questionnaire to assess the symptoms of the nose and airways for rhinosinusitis |
Countries
Brazil
Outcome results
None listed