Menopause, Sexual Abstinence
Conditions
Keywords
postmenopausal, hypoactive, sexual disorder, androgen
Brief summary
Hypoactive Sexual Desire Disorder ( HSDD ) is very common in postmenopausal women due to a reduction in circulating androgen levels. The aim of this study is to evaluate the effects of Tribulus Terrestris in premenopausal women with HSDD.
Detailed description
Hypoactive Sexual Desire Disorder ( HSDD ) is the most prevalent female sexual dysfunction in society mainly in postmenopausal women, and is strongly linked to the quality of life of women . The androgen hormones decline over age in the premenopausal period, more sharply after menopause. Tribulus terrestris is a plant native to India , recommended in the treatment of infertility , low libido and impotence . Its main active ingredient is the protodioscin , which has been attributed to an increase in testosterone levels and improved sexual function . The aim of this study is to evaluate the effects of Tribulus Terrestris in premenopausal women with HSDD .
Interventions
patients will use 750 mg/day during 120 days
OTHERPlacebo
patients will use placebo pills with the same shape of the drug
Sponsors
Federal University of Minas Gerais
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* at least one year after last menstrual period * with no use of hormonal replacement therapy within the last 3 months * without any medication, drugs or alcohol. * Healthy patients without systemic or psychiatric disease
Exclusion criteria
* Patient smoker (10 cigarettes per day). * Patients with blood pressure \> 160/90 mm Hg. * Patient with breast or endometrial carcinoma. * Patients with a history of myocardial infarction. * Patient with Diabetes. * Patient with vaginal bleeding from any source. * Patients with hepatic injury. * Patients with active thrombophlebitis or thromboembolic disorders recent * Patients with interpersonal relationship problems with your relationship or partner * Patients with sexual problems from your partner
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sexual Desire | 120 days | we will use the Quotient Sexual - Version Feminine (QS-F) brazilian questionary to make the evaluation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| serum levels of prolactin and thyroid-stimulating hormone (TSH) | 120 days | Blood test |
Other
| Measure | Time frame | Description |
|---|---|---|
| serum levels of testosterone and sex hormone-binding globulin (SHBG) | 120 days | Blood test |
Countries
Brazil
Outcome results
None listed