Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21

Efficacy of the Addition of Silver Nanoparticles to a Fluor Varnish in the Remineralization of Temporary Teeth in Patients With Trisomy 21. Randomized Clinical Trial.

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01975545

Enrollment

Registered

2013-11-04

Start date

2012-09-30

Completion date

2014-05-31

Last updated

2014-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Down Syndrome

Keywords

Down syndrome, Caries, Dental varnish

Brief summary

Patients with trisomy 21 are in greater danger of developing caries. It has been hypothesized that adding silver nanoparticles to fluor varnishes could promote remineralization of the teeth. A split-plot randomized controlled trial will be performed to address this question.

Interventions

DRUGFluor varnish

Dental varnish will be applied to one anterior superior teeth in a random side.

DRUGFluor varnish with nanoparticles

Dental varnish with silver nanoparticles will be applied to one anterior superior teeth in a random side.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

1 Years to 6 Years

Healthy volunteers

Inclusion criteria

* Patients with trisomy 21 diagnosed through caryotype * Age 1 to 6 years old * Any sex * White spot present in both upper anterior teeth * Parental agreement to participate in the study

Exclusion criteria

* Hypersensibility to any of the substances used * Non cooperating patients * Caries in enamel or dentine in the upper anterior teeth * Leukemia or diabetes * Dental fluorosis present

Design outcomes

Primary

Measure	Time frame	Description
Remineralization	3 months	Remineralization status will be assessed through laser fluorescence of the tooth with a Diagnodent probe (Diagnodent, Kavo, Madrid, Spain)

Countries

Mexico

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026