Hemodialysis Frequency and the Calcification Propensity of Serum

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01975025

Acronym

Intensified HD

Enrollment

Registered

2013-11-04

Start date

2014-06-30

Completion date

2014-08-31

Last updated

2016-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anuria, Hemodialysis

Keywords

Renal Dialysis

Brief summary

The aim of this clinical research project is to test the hypothesis that daily dialysis has favorable effects on the calcification propensity of human serum, when determined by the investigators' newly developed in vitro serum test. The investigators' hypothesis is that shorter interdialytic intervals will result in an improved calcification propensity of serum. The determination of serum calcification has the potential to become a novel measure of dialysis quality in the future.

Detailed description

Background The serum calcification test has been established and validated by A. Pasch and coworkers, the expertise to perform the necessary statistical analyses is present in the investigator's department, all patient-related procedures necessary for this project are routinely performed in the investigator's department. Objective Does short daily hemodialysis strengthen the calcification-inhibitory forces inherent in hemodialysis patient sera, when compared to conventional three-times weekly hemodialysis? Methods Serum calcification test

Interventions

PROCEDUREShort daily dialysis for 2 weeks

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Chronic hemodialysis \>3 months * Anuria (\<100ml urine per day) * Written informed consent

Exclusion criteria

* Citrate dialysis * Significant fistula recirculation (\>15%) * Infection

Design outcomes

Primary

Measure	Time frame
Change from baseline calcification propensity of serum	6 weeks

Secondary

Measure	Time frame
Change from baseline of sodium, potassium, calcium, phosphate, magnesium, albumin, protein, hematocrit and their correlation with calcification propensity of serum	6 weeks

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026