Male Infertility
Conditions
Keywords
Metabolic syndrome, Epigenetic, Male infertility, Sperm parameters, Biomarkers
Brief summary
Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility
Detailed description
Assessment of sperm parameters and metabolic syndrome relations in men attending a Reproductive Biomedicine centre for an infertility of their couple. Secondary objectives are to study relationship between sperm parameters and: * adiposity and insulin resistance * inflammation * oxydative stress in blood and semen * hormonal status Innovative parameters will also be assessed to determine the quality of semen (length of fingers, wrist circumference and epigenetics studies)
Interventions
OTHERBlood sample, sperm sample and clinical examens
Blood sample, sperm sample and clinical examens will be done at the day of the inclusion
Sponsors
URC-CIC Paris Descartes Necker Cochin
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* 18 to 45 years-old man * man consulting for primary or secondary infertility, with or without earlier notion of paternity * patient insured with a social security scheme * patient who have had a prior medical consultation * patient who have done informed and written consent to participate in the research study
Exclusion criteria
* patient with problems understanding French * patient smoking more than two-pack-a-day * patient monitoring for viral risk. * man with an unidiopathic infertility which may be explained by: 1\) identifiable factors in direct questioning at the sperm analysis: * exposure to toxic products * infectious disease history * pathological anatomical background 2) factors identified at the etiologic investigation: cytogenetic and genetic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of spermatozoid and their relation with syndrome metabolic parameters | Day 0 | We will measure the parameters of metabolic syndrome (triglycerides, HDL and LDL cholesterol, systolic and diastolic blood pressure, fasting glucose) and correlate them with the number of spermatozoid . |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between spermogram and spermocytogram and other metabolic parameters | Day 0 | Relationship between other spermogram/spermocytogram and metabolic markers (biomarkers and anthropometric adiposity and insulin resistance) |
| Environmental parameters | Day 0 | Evaluation of environmental parameters (physical activity, tobacco consumption, quality of life) by classical questionnaire |
Countries
France
Outcome results
None listed