The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans

Conditions

Hemodynamics

Keywords

Cardiac physiology, ageing, gender differences, diastole, fluid challenge

Brief summary

Primary: To observe how hemodynamic parameters are affected by age during rest and exercise in healthy humans. Furthermore, how an acute fluid challenge changes hemodynamic parameters. Secondary: To thoroughly examine this population with regard to cardiac performance and function, anthropometrics, metabolic status, exercise capability, constitution, pulmonary status, and humoral markers of organ functions. This population will serve as a healthy control group, to which different populations can be compared, hence the need for a comprehensive characterization. Hypotheses: Diastolic function and parameters associated with diastolic function gradually deteriorate with increasing age. The gradual deterioration is unmasked at an earlier age during exercise and fluid challenge, compared to measurements made at rest.

Mads J. Andersen, Emil Wolsk, Rine Bakkestrøm, Nicolaj Lyhne Christensen, Rasmus Carter‐Storch et al. (12 authors)

Heart2022-08-298 citations

10.1136/heartjnl-2022-321204

Hemodynamic Response to Rapid Saline Infusion Compared with Exercise in Healthy Participants Aged 20-80 Years.

Andersen MJ, Wolsk E, Bakkestrøm R, Thomsen JH, Balling L, Dahl JS, Gustafsson F, Møller JE, Hassager C.

2019-06-179 citations

10.1016/j.cardfail.2019.06.004

Cardiac remodelling and haemodynamic characteristics in primary mitral valve regurgitation

Rine Bakkestrøm, Ann Banke, Redi Pecini, Akhmadjon Irmukhamedov, Søren K. Nielsen et al. (8 authors)

Open Heart2018-12-016 citations

10.1136/openhrt-2018-000919

Interventions

OTHERExercise

Study design

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Age over 18 years * No acute or chronic diseases that can influence hemodynamics * Pause in medication with effect on hemodynamics 24h before experimental day * Echocardiography, with no structural abnormalities with an impact on hemodynamics. * ECG without any pathological findings, including arrhythmia * Normal red and white blood count, normal renal, liver, thyroid, immune, and hematological function as well as normal electrolytes, HbA1c and natriuretic peptides * Ability to perform graded bicycle exercise testing * BMI in the range of 20-30 kg/m2 * Height within population mean ±2 standard deviations * VO2-max within population mean ±2 standard deviations (age corrected) * Acceptable sonographic conditions * Informed consent

Exclusion criteria

* History of heart failure (verified or suspected), or heart failure verified by pathological left and right systolic and diastolic measurements of the heart * Hypotension (systolic blood pressure \< 100 mmHg) * Inability to participate * Pregnant women * Diabetes

Design outcomes

Primary

Measure	Time frame	Description
Composite of hemodynamic parameters	minutes	Invasive measurements using Swan-Ganz catheters and echocardiography will provide the data needed.

Secondary

Measure	Time frame	Description
Composite of humoral markers	up to 1 hour	Blood samples will be analysed with regard to humoral peptides and hormones that may affect hemodynamics.

Countries

Denmark

Outcome results

None listed