Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting

A Comparison of Histologic and Immunohistochemical Characteristics Between the Upper and Lower Leg Saphenous Veins Used for Coronary Artery Bypass Grafting

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01974492

Acronym

COSAVEGUL-1

Enrollment

Registered

2013-11-01

Start date

2013-10-31

Completion date

2016-06-30

Last updated

2016-07-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction, Stable Angina, Triple Vessel Disease, Unstable Angina

Keywords

saphenous vein graft, composite graft, coronary artery bypass grafting, graft remodeling

Brief summary

In coronary artery bypass grafting, saphenous veins are widely used as a composite grafts that are Y-anastomosed to in-situ left internal thoracic artery. Based on our observation that remodeling of saphenous vein graft differs between those harvested from upper leg vein and lower leg, this study aims to compare histologic and immunohistochemical findings between saphenous vein grafts harvested from upper leg and lower leg.

Detailed description

Inclusion criteria: * Patients aged from 40 to 75 years with triple vessel disease * Patients who are eligible for the use of left internal thoracic artery as an in situ primary conduit * Operation plan: saphenous vein graft will be Y-anastomosed to left internal thoracic artery. * Patients whose saphenous vein grafts can be harvested from both upper legs and lower legs * Patients who are eligible for off-pump coronary artery bypass grafting * Patients who agreed with the participation in the research based on thorough explanation. Patients will be randomly assigned to upper leg vein (ULV) group and lower leg vein (LLV) group immediately after anesthetic induction. Pieces of residual saphenous vein graft will be sent for histologic and immunohistochemical examination for the evaluation of endothelial cell preservation and the expression of matrix proteins.

Interventions

PROCEDUREUpper leg vein harvesting

Patients whose saphenous veins are harvested from upper legs.

PROCEDURELower leg vein harvesting

Patients whose saphenous veins are harvested from lower legs.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients with multivessel disease who were planned to undergo off-pump coronary artery bypass grafting * Patients whose left internal thoracic arteries can be used, and whose saphenous vein grafts will be Y-anastomosed to left internal thoracic arteries. * Patients whose saphenous vein grafts can be harvested from both upper and lower legs.

Exclusion criteria

* Patients with overt heart failure symptoms * Patients with intractable ventricular arrhythmia * Patients with history of cancer or malignancy * Patients with coagulation or other hematologic disorder * Patients who needs concomitant cardiac procedures

Design outcomes

Primary

Measure	Time frame	Description
Endothelial preservation of saphenous vein graft	1 year	Participants will be followed for the duration of hospital stay, an expected average of 1 week.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026