Erosive and Atrophic Oral Lichen Planus
Conditions
Keywords
oral lichen planus, cedar honey, atrophic, erosive, pain, treatment, clinical trial
Brief summary
The study aimed to evaluate the effect of cedar honey in treatment of erosive and atrophic oral lichen planus ( a common oral problem).
Interventions
DRUGorally administered cedar honey
Sponsors
Mashhad University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. clinically and histopathologically confirmed oral lichen planus without dysplasia in histopathologic evaluation 2. Severity of pain≥2 (VAS score) 3. Severity of lesions≥2 (tong prasom criteria) 4. absence of any treatment in the last month 5. absence of kidney or liver diseases( due to systemic administration of fluconazole to both groups)
Exclusion criteria
1. evidence of lichenoid reaction in clinical or histopathologic assessment 2. loss of follow up 3. pregnant patients 4. diabetic patients 5. any other mucosal disease 6. any severe systemic disease 7. patients who refuse doctor's advice 8. any unexpected adverse effect of honey
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| severity of lesions | 4 weeks | severity of lesions due to thong prasom criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| size of lesions | 4 weeks | A sterile caulis was used to measure the maximum diameter of erosive and atrophic lesions and the maximum width perpendicular to the maximum diameter was recorded. |
Other
| Measure | Time frame | Description |
|---|---|---|
| pain of lesions | 4 weeks | Pain or burning sensation was assessed by using a visual analog scale (VAS). Patients marked the point from 0(no pain) to 10(extreme pain) representing their present pain perception |
Countries
Iran
Outcome results
None listed