Diabetes, Prediabetes
Conditions
Keywords
Postprandial period, triglyceride, Diabetes mellitus, type 2, Prediabetic state
Brief summary
The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because of non-fasting state for more than 12 hours and importance of triglyceride-rich lipoprotein. We aim to investigate the relationship of postprandial triglyceride after fat tolerance test and intima-medial thickness and to suggest normal reference of postprandial triglyceride after fat tolerance test. In addition, we evaluate the correlation of postprandial triglyceride and incretin secretion after fat tolerance test Ultimately, we want to estimate clinical importance of postprandial triglyceride in assessment of cardiovascular risk.
Interventions
DIETARY_SUPPLEMENTOral fat tolerance test
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* age : 19 \ 70 yrs * Type 2 diabetes : HbA1c \<10% * Prediabetic state : HbA1c 5.7\ 6.4%
Exclusion criteria
* Type 1 diabetes, secondary diabetes * dipeptidyl peptidase-4 -inhibitor, glucagon-like peptide-1 agonist, thiazolidinediones users * Thyroid disease with abnormal thyroid function test * Liver disease with abnormal liver function test * severe kidney disease * pregnant or lactating women * current smoker * severe obesity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of Triglyceride | 8 hours | Blood sample : drawn by a catheter before the meal and every 1 hour after meal over the 8-hour period |
Secondary
| Measure | Time frame |
|---|---|
| Changes of incretin | 8 hours |
Countries
South Korea
Outcome results
None listed