Sevoflurane Protective Effect on Ischemia Reperfusion Injury in Microvascular Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01972230

Enrollment

128

Registered

2013-10-30

Start date

2013-01-31

Completion date

Unknown

Last updated

2016-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Microvascular Breast Flap in Plastic Surgery

Brief summary

This study aimed to evaluate the possible protective effect of anesthetic technique balanced (BAL) compared to total intravenous anesthetic technique (TIVA-TCI) in ischemia reperfusion injury in microvascular flap in plastic surgery. The investigators will evaluate the viability of the flap using tissue oximetry monitoring and the level of biochemical markers in a circle at the end of the intervention.

Interventions

DRUGSevoflurane

DRUGDiprivan + Remifentanil TCI

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* age \> 18 yr * ASA (American Society of Anesthesiology) I-II

Exclusion criteria

* Known unusual reaction to anesthetic drugs * Evaluation of anesthesia increased risk for malignant hyperthermia. * History of vascular disease. * History of bleeding diathesis. * Tabagism

Design outcomes

Primary

Measure	Time frame
tissutal oximetry average value of the flap measured with INVOS (In Vivo Optical Spectroscopy) system continuously.	24 hours from the end of intervention

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026