Parkinson Disease(PD)
Conditions
Keywords
Muscle strength, fatigue, electromyography (EMG), central fatigue, strength straining
Brief summary
Fatigue is one of the most common symptoms in individuals with Parkinson's Disease (PD). Past research indicated that more than half of the individuals with PD demonstrated fatigue symptom. The severity of fatigue was also correlated to the quality of life in individuals with PD. Finding the contributions of the central and the peripheral factors to fatigue and developing an effective training program for individuals with PD are very important. Fatigue can be categorized into peripheral or central causes. The central fatigue and voluntary activation failure originate from the decrease in motivation or the reduction of the conduction within corticospinal tracts. Long term activation failure and central fatigue will cause disuse of muscle and result in peripheral weakness and peripheral fatigue. Quantifying the weighting of central versus peripheral factors contributing to the fatigue in people with PD is important. Most of the conventional strength and endurance training programs were based on the researches of young groups. Almost no training program was design for enhancing the voluntary activation level and relief the central fatigue. Seeking an appropriate training program to enhance central activation is very important for individuals with PD who prone to fatigue. Previous studies have shown that increasing afferent input by peripheral electrical stimulation (ES) at sensory threshold enhanced the plasticity of contralateral primary sensory cortex, the excitability of corticospinal tracts, and the functional performance in young adults. Combining afferent input with strength training was more effective than strength training along. ES, which is easy to quantify the dose of afferent input, is a feasible method to provide such training. The purpose of this project is to investigate the effects of the combination of ES at sensory threshold and strength training on voluntary activation in the individuals with PD.
Interventions
Participants will perform 8 weeks of electrical stimulation for Quadriceps muscle belly(30 minutes/time, 3 times/week).
Participants will perform 8 weeks of isotonic contraction muscle strength training for lower extremities.
Sponsors
Chang Gung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Health subjects:
Exclusion criteria
* Musculoskeletal injuries for knee. * Osteoporosis. * Diabetes. PD subjects: Inclusion Criteria: * Clinical diagnosis of Parkinson disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle twitch force | baseline, 8 weeks. | Measure of changes in muscle twitch force by interpolation twitch technique. |
| Muscle voluntary activity level | Baseline,8 weeks | Measure of changes in muscle voluntary activity level by interpolation twitch technique. |
| Muscle strength test for lower extremities. | Baseline, 8 weeks | Measure of changes in muscle strength test by clinical test. |
| The central activation and the excitability of motor cortex | Baseline,8 weeks | Measure of changes in the central activation and the excitability of motor cortex by Transcranial magnetic stimulation. |
Countries
Taiwan
Outcome results
None listed