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Gastric Emptying and Insulin Response to Test Drink

Assessment of Insulin Response Following Ingestion of a Carbohydrate/Whey Protein Drink. A Cross-over Randomized Double Blind Study.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01971229
Enrollment
15
Registered
2013-10-29
Start date
2013-12-31
Completion date
2015-07-31
Last updated
2018-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Resistance

Brief summary

Surgery is a stress on the body and recovering well after surgery is very important to patients and their doctors. It is therefore important to prepare patient's bodies for the stress of surgery, and one way to do this is to provide proper nutrition. In the past, patients were asked to prepare for surgery by fasting from midnight before surgery. Today, it is known that this practice is not beneficial to patient's recovery. In fact, it has been recognized that drinking a sugary beverage (e.g., juice) before surgery stimulates the production of insulin, which is a hormone that helps make the proteins needed for wound healing after surgery. This is currently practiced at the MUHC. It might also be beneficial, however, to drink a beverage that contains sugar and whey proteins (a protein isolated from milk) before surgery. In fact, whey proteins stimulate insulin and may also have the added benefit of improving muscular strength. In this study, investigators will measure the level of insulin produced after drinking a carbohydrate (i.e., sugar)-whey protein beverage to determine how it compares to the level of insulin produced after drinking the sugary beverage used at the MUHC.

Detailed description

It is hypothesized that the increase in plasma insulin following a mixed carbohydrate whey protein drink is significantly greater than that elicited by a carbohydrate drink.

Interventions

OTHERCarbohydrate based drink

After consumption of the test drink to record the insulin response and gastric emptying.

OTHERWhey protein based drink

After consumption of the test drink to record the insulin response and gastric emptying.

Sponsors

Franco Carli
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

\- Healthy volunteer

Exclusion criteria

* diabetes, * neurological disorders * chronic kidney failure * chronic liver disease * disorders of gastric motility * gastro-esophageal reflux * achalasia * gastroparesis * intestinal obstruction * previous abdominal surgery * lactose intolerance * body mass index below 17 or above 29 * allergy to acetaminophen.

Design outcomes

Primary

MeasureTime frameDescription
Insulin response to a test mealChange over 3 hoursPatients will consume a carbohydrate or a whey protein based drink and their insulin response will be monitored every 30 minutes for 3 hours.

Secondary

MeasureTime frameDescription
Gastric emptyingChange over 3 hoursThe acetaminophen absorption test, as an indirect assessment of gastric emptying.Since gastric emptying is the rate-limiting step in delivering the drug to its absorption site, it is believed that the rate of appearance of acetaminophen in the blood reflects the rate of gastric emptying. Blood samples will be collected every 30 minutes for 3 hours.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026